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首页> 外文会议>Conference on biomedical applications of micro- and nanoengineering IV and complex systems; 20081210-12; Melbourne(AU) >Development of a wireless intra-ocular pressure monitoring system for incorporation into a therapeutic glaucoma drainage implant
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Development of a wireless intra-ocular pressure monitoring system for incorporation into a therapeutic glaucoma drainage implant

机译：开发一种用于合并治疗性青光眼引流植入物的无线眼压监测系统

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摘要

Glaucoma is a common cause of blindness. Wireless, continuous monitoring of intraocular pressure (IOP) is an important, unsolved goal in managing glaucoma. An IOP monitoring system incorporated into a glaucoma drainage implant (GDI) overcomes the design complexity associated with incorporating a similar system in a more confined space within the eye. The device consists of a micro-electro-mechanical systems (MEMS) based capacitive pressure sensor integrated with an inductor printed directly onto a polyimide printed circuit board (PCB). The device is designed to be incorporated onto the external plate of a therapeutic GDI. The resonance frequency changes as a function of IOP, and is tracked remotely using a spectrum analyzer. A theoretical model for the reader antenna was developed to enable maximal inductive coupling with the IOP sensor implant. Pressure chamber tests indicate that the sensor implant has adequate sensitivity in the IOP range with excellent reproducibility over time. Additionally, we show that sensor sensitivity does not change significantly after encapsulation with polydimethylsiloxane (PDMS) to protect the device from fluid environment. In vitro experiments showed that the signal measured wirelessly through sheep corneal and scleral tissue was adequate indicating potential for using the system in human subjects.
机译：青光眼是失明的常见原因。无线，连续监测眼内压（IOP）是控制青光眼的重要而未解决的目标。合并到青光眼引流植入物（GDI）中的IOP监视系统克服了在眼睛更狭窄的空间中合并类似系统所带来的设计复杂性。该设备由基于微机电系统（MEMS）的电容式压力传感器组成，该传感器与直接印刷在聚酰亚胺印刷电路板（PCB）上的电感器集成在一起。该设备设计为可结合到治疗性GDI的外部板上。谐振频率随IOP的变化而变化，并使用频谱分析仪进行远程跟踪。开发了用于读取器天线的理论模型，以实现与IOP传感器植入物的最大电感耦合。压力室测试表明，传感器植入物在IOP范围内具有足够的灵敏度，并且随时间推移具有出色的可重复性。此外，我们表明，用聚二甲基硅氧烷（PDMS）封装以保护设备免受流体环境影响后，传感器灵敏度不会发生明显变化。体外实验表明，通过羊角膜和巩膜组织无线测量的信号足以表明该系统在人类受试者中使用该系统的潜力。

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