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首页> 外文会议>Conference on BioMEMS and Nanotechnology; 20071205-07; Canberra(AU) >Bioimprint Replication Of Single Cells On A Biochip
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Bioimprint Replication Of Single Cells On A Biochip

机译：在生物芯片上单细胞的生物印迹复制

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We are investigating the use of nanoscale imaging technologies that might help in the fundamental understanding of cell function and lead to early diagnosis of diseases at a single cell and molecular level. A new method has been developed that integrates nanoimprint lithography directly with biological materials to create replica cell impressions in robust storage medium to facilitate topographical analysis using Atomic Force Microscopy. Termed Bioimprint~(TM) , soft lithography techniques are used to transfer precise cell topography into polymeric composite for imaging in harsh probing or electron beam environments. By creating a permanent biological print that is captured in a specific moment of time, a recorded response of cellular events can be stored. The high resolution transfer of this process is illustrated by imaging membrane morphological structures consist with exocytosis, in pituitary cells. The integration of soft lithography and biological materials presents a novel method for the study and detection of biological systems at the nano scale. Applications of this technique to cancer cells has also been investigated.
机译：我们正在研究纳米成像技术的使用，这些技术可能有助于对细胞功能的基本了解，并导致在单个细胞和分子水平上早期诊断疾病。已经开发出一种新方法，该方法将纳米压印光刻技术与生物材料直接集成在一起，以在坚固的存储介质中创建复制细胞印模，以利于使用原子力显微镜进行形貌分析。软光刻技术被称为BioimprintTM，用于将精确的细胞形貌转移到聚合物复合材料中，以便在恶劣的探测或电子束环境中成像。通过创建在特定时间段捕获的永久性生物图像，可以存储细胞事件的记录响应。该过程的高分辨率转移通过对垂体细胞中胞吐作用的膜形态结构进行成像来说明。软光刻和生物材料的集成为纳米级生物系统的研究和检测提供了一种新颖的方法。还研究了该技术在癌细胞上的应用。

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