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首页> 外文会议>Conference on BioMEMS and Nanotechnology; 20071205-07; Canberra(AU) >Induced movement of the magnetic beads and DNA-based Dumbbell in a micro fluidic channel
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Induced movement of the magnetic beads and DNA-based Dumbbell in a micro fluidic channel

机译：在微流体通道中诱导磁珠和基于DNA的哑铃运动

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摘要

We have explored controlled movement of magnetic beads and a dumbbell structure composed of DNA, a magnetic and a non-magnetic bead in a micro fluidic channel. Movement of the beads and dumbbells is simulated assuming that a net force is described as a superposition between the magnetic and hydrodynamic drag forces. Trajectories of beads and dumbbells are observed with optical light microscopy. The experimentally measured data show a good agreement with the simulations. This dynamical approach offers the prospect to stretch the DNA within the dumbbell and investigate its conformational changes. Further on, we demonstrate that short sonication can reduce multiple attachments of DNA to the beads.
机译：我们已经研究了磁珠的受控运动，以及由微流体通道中的DNA，磁珠和非磁珠组成的哑铃结构。假设将净力描述为磁力和流体动力阻力之间的叠加，则模拟了珠和哑铃的运动。用光学显微镜观察珠和哑铃的轨迹。实验测得的数据与模拟结果吻合良好。这种动力学方法为在哑铃中拉伸DNA并研究其构象变化提供了前景。进一步，我们证明了短时间的超声处理可以减少DNA与磁珠的多次附着。

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