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首页> 外文会议>Conference on Coherence Domain Optical Methods in Biomedical Science and Clinical Applications Ⅵ Jan 21-23, 2002 San Jose, USA >Functional Imaging of Cat Primary Visual Cortex with Optical Coherence Tomography
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Functional Imaging of Cat Primary Visual Cortex with Optical Coherence Tomography

机译：猫主要视觉皮层的功能性成像与光学相干断层扫描。

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摘要

We report the application of Optical coherence tomography (OCT) for visualizing a one dimensional depth resolved functional structure of cat brain in vivo. The OCT system is based on the known fact that neural activation induces structural changes such as capillary dilation and cellular swelling. Detecting these changes as an amplitude change of the scattered light, an OCT signal reflecting neural activity i.e., fOCT (functional OCT) could be obtained. Experiments have been done to obtain a depth resolved stimulus-specific profile of activation in cat visual cortex. Our results in one dimension indicate that indeed an orientation dependent functional signal could be obtained. Further, we show that this depth resolved fOCT signal is well correlated with the stimulus dependent column determined by OISI. Based on the results, the smallest functional unit in depth, resolved by the proposed system is around 40μm. We are extending our system to perform two dimensional functional imaging.
机译：我们报告了光学相干断层扫描（OCT）的可视化猫脑在体内的一维深度解析功能结构的应用。 OCT系统基于已知的事实，即神经激活会引起结构变化，例如毛细血管扩张和细胞肿胀。将这些变化检测为散射光的幅度变化，可以获得反映神经活动的OCT信号，即fOCT（功能性OCT）。已经进行了实验以获得猫视皮质中激活的深度分辨的刺激特异性分布图。我们在一维的结果表明，确实可以获得与方向有关的功能信号。此外，我们表明，该深度解析的fOCT信号与OISI确定的依赖于刺激的列具有很好的相关性。根据结果​​，所提出的系统所解析的最小深度功能单元约为40μm。我们正在扩展我们的系统以执行二维功能成像。

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