• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Conference on Computability in Europe(CiE 2005); 20050608-12; Amsterdam(NL) >Recombinant DNA, Gene Splicing as Generative Devices of Formal Languages
【24h】

Recombinant DNA, Gene Splicing as Generative Devices of Formal Languages

机译：重组DNA，基因剪接作为形式语言的生成装置

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recombinant DNA (rDNA) is a general term which refers to the DNA resulting from the process of combining a piece of one DNA with another strand of DNA. More precisely recombinant DNA is obtained from two or more different sources that have been cleaved by restriction enzymes and joined by ligases: this biological mechanism is known as gene splicing. Recently, recombinant DNA technology has received a rapid increase in interest in Molecular Biology, aimed at the development of biotechnologies. On the other hand, the surprising power of this process are stimulating interest towards the design of computational models inspired by biological phenomena. In this perspective, formal language theory appears to be a natural framework for formalizing and investigating DNA computing models. In 1987 Tom Head pioneered a language-theoretic approach for studying splicing and recombinant DNA. He introduced the splicing systems, abstract models which are a formal counterpart of the DNA recombination under the action of restriction and ligase enzymes. A splicing operation, as a model of gene splicing, is introduced as an operator on strings. There are at least three different definitions of this operation, given by Head, Paun and Pixton respectively. A splicing system is defined by giving an initial language I (simulators of the initial set of DNA molecules) and a set of special words or rules R (simulating the enzymatic action). The set I is then transformed by repeated applications of the splicing operation. In Nature DNA occurs in both linear and circular form and circular splicing occurs in a recombinant mechanism (transposition) between bacteria and plasmids, that are circular DNA molecules. Depending on the DNA form and on the definition of the splicing operation we refer to, we have different definitions of linear splicing systems and of circular splicing systems.
机译：重组DNA（rDNA）是一个通用术语，是指将一个DNA片段与另一条DNA链结合在一起的过程产生的DNA。更准确地说，重组DNA是从两种或更多种不同的来源获得的，这些来源已被限制酶切割并通过连接酶连接：这种生物学机制称为基因剪接。最近，针对生物技术的发展，重组DNA技术对分子生物学的兴趣迅速增加。另一方面，此过程的惊人功能激发了人们对受生物学现象启发的计算模型设计的兴趣。从这个角度来看，形式语言理论似乎是形式化和研究DNA计算模型的自然框架。 1987年，汤姆·黑德（Tom Head）率先提出了一种语言理论方法，用于研究剪接和重组DNA。他介绍了剪接系统，抽象模型，这些模型在限制性酶和连接酶的作用下是DNA重组的正式对应物。作为基因剪接的模型，剪接操作作为字符串的运算符引入。该操作至少有三种不同的定义，分别由Head，Paun和Pixton给出。通过提供初始语言I（DNA分子初始组的模拟程序）和一组特殊单词或规则R（模拟酶促作用）来定义拼接系统。然后通过重复应用拼接操作来变换集合I。在自然界中，DNA以线性和环状形式存在，环状剪接以细菌和质粒（环状DNA分子）之间的重组机制（转座）发生。根据DNA形式和所指的剪接操作的定义，我们对线性剪接系统和圆形剪接系统有不同的定义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号