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首页> 外文会议>Conference on Environmental Pollution and Public Health >Effects of Asian Sand Dust on Allergic Airway Inflammation in Mice
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Effects of Asian Sand Dust on Allergic Airway Inflammation in Mice

机译：亚洲沙尘对小鼠过敏性气道炎症的影响

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There is no experimental study demonstrating the effects of airborne Asian sand dust (ASD) on allergic lung eosinophilia.The organic substances adsorbed onto ASD collected from the atmosphere of Iki-island in Japan were excluded by heat treatment at 360℃ for 30 min.The effects of ASD or heated-ASD (H-ASD) towards allergic lung inflammation were compared in murine lungs to investigate the role of organic substances.ICR mice were administrated with the two kinds of ASD and/or ovalbumin (OVA) intratracheally four times at 2-week intervals.ASD and H-ASD enhanced eosinophil recruitment induced by OVA in the the airway.ASD and H-ASD synergistically increased Th2 cytokines-interleukin-13 (IL-13),eosinophil-relevant cytokine and chemokine,such as IL-5,and monocyte chemotactic protein-3 (MCP-3) induced by OVA in whole lung lavage fluid.The enhancing effects were much greater in ASD than in H-ASD.These results suggest that the aggravated lung eosinophilia in ASD is due to activation of a Th2-associated immune response and microbial materials could be participating in this phenomenon.
机译：目前尚无任何实验研究证明亚洲空运沙尘（ASD）对过敏性肺嗜酸性粒细胞增多的影响。通过从日本Iki-island大气中收集的吸附在ASD上的有机物质在360°C热处理30分钟后被排除。比较小鼠肺中ASD或加热ASD（H-ASD）对变应性肺炎症的影响，以研究有机物质的作用.ICR小鼠在气管内分别经四次气管内注射两种ASD和/或卵清蛋白（OVA）。每隔2周一次.ASD和H-ASD增强了由OVA在气道中诱导的嗜酸性粒细胞募集.ASD和H-ASD协同增加了Th2细胞因子-白介素13（IL-13），嗜酸性粒细胞相关的细胞因子和趋化因子（如IL） -5和OVA在全肺灌洗液中诱导的单核细胞趋化蛋白3（MCP-3）。ASD的增强作用比H-ASD大得多。这些结果表明，ASD中肺嗜酸性粒细胞增多是由于Th2-ass的激活相关的免疫反应和微生物物质可能参与了这一现象。

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