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首页> 外文会议>Conference on Instruments, Methods, and Missions for Astrobiology V, Aug 22-23, 2002, Waikoloa, Hawaii, USA >Origins of the protein synthesis machinery: a genomics and structural perspective
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Origins of the protein synthesis machinery: a genomics and structural perspective

机译：蛋白质合成机制的起源：基因组学和结构观点

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摘要

The protein synthesis machinery is believed to have largely evolved before the last common ancestor of life on Earth as we know it. Thus, an understanding of ribosomal history will provide insight to the transition period between the last common ancestor and the RNA World. It is argued here that much of this history has been preserved in the primary sequences and three-dimensional structures of the various ribosomal components. In order to understand this history, it is necessary to identify timing insights that can provide clues to the relative age of various aspects of the ribosomal machinery. Such information can be obtained in a variety of ways. Several examples of how such information might be obtained are discussed. Finally, a tentative outline of the order of major events in ribosome history is presented.
机译：我们认为，蛋白质合成机制在地球上生命的最后共同祖先之前已经有了很大的发展。因此，对核糖体历史的了解将提供对最后一个共同祖先与RNA世界之间过渡期的见识。这里争论的是，许多历史已经保存在各种核糖体成分的主要序列和三维结构中。为了了解此历史，有必要确定定时洞察力，以提供有关核糖体机器各个方面的相对年龄的线索。这样的信息可以通过多种方式获得。讨论了如何获取此类信息的几个示例。最后，初步概述了核糖体历史上主要事件的顺序。

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