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首页> 外文会议>Conference on Laser Florence 2001: A Window on the Laser Medicine World, Nov 7-11, 2001, Florence, Italy >Studies on cytostatics used as photosensiting materials in photodynamic therapy
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Studies on cytostatics used as photosensiting materials in photodynamic therapy

机译：细胞抑制剂在光动力疗法中作为光敏材料的研究

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Introduction of the photosensitizer properties of cytostatics drus was made, pointing out the fact that besides the biochemical action of the cytostatics their effects could be enhanced by the exposure to ligth at different doses. A spectroscopical characterisation of methotrexate and fluorouracil, cytostatic drugs used frequently in cancer therapy was performed. The absorption, emission and excitation spectra were measured for methotrexate solutions in natural saline and sodium hydroxide at concentration in the range 10~(-5) -10~(-6)M and pH 8.4. The absorption, emission and excitation spectra were measured for fluorouracil solutions in natural saline at concentration in the range 10~(-4) -10~(-5)M. The absorption spectrum exhibits spectral bands in the range 250nm - 450nm for both drugs. The fluorescence excitation for methotrexate was made at 340nm and 370nm, the fluorescence emission was detected in the spectral range 400nm - 500nm with a maximum at 470nm. The fluorescence excitation was measured in the range 200nm-500nm with the emission centred on 530nm, for Xe lamp irradiation, and 330nm for Hg lamp and laser irradiation. The fluorescence emission spectra was monitored in the spectral range 400nm - 600nm The effects of irradiation on spectroscopic characteristics of methrotrexate and fluorouracil were investigated. The irradiation was made using a UV classic lamp with Xe, for the first experimental part and for the second one it was used both a classic Hg lamp and a nytrogen pulsed laser.
机译：介绍了细胞抑制剂的光敏剂特性，指出了这样一个事实，除了细胞抑制剂的生化作用外，通过暴露于不同剂量的ligth可以增强它们的作用。进行了甲氨蝶呤和氟尿嘧啶，在癌症治疗中经常使用的细胞抑制药物的光谱表征。测定了氨甲re呤溶液在天然盐水和氢氧化钠中的吸收，发射和激发光谱，浓度范围为10〜（-5）-10〜（-6）M，pH 8.4。测定了天然盐水中氟尿嘧啶溶液在10〜（-4）-10〜（-5）M范围内的吸收，发射和激发光谱。两种药物的吸收光谱均显示在250nm-450nm范围内的光谱带。在340nm和370nm处进行甲氨蝶呤的荧光激发，在400nm至500nm的光谱范围内检测到荧光发射，最大值在470nm处。在200nm-500nm范围内测量荧光激发，对于Xe灯辐照，发射中心在530nm，对于Hg灯和激光辐照，发射中心在330nm。在400nm-600nm的光谱范围内监测荧光发射光谱。研究了辐照对甲氨蝶呤和氟尿嘧啶光谱特性的影响。使用带有Xe的UV经典灯进行辐照，对于第一实验部分，对于第二实验部分，同时使用经典Hg灯和氮气脉冲激光。

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