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首页> 外文会议>Conference on Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III Jan 26-27, 2003 San Jose, California, USA >Pigmentation in NIR Laser Tissue Damage
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Pigmentation in NIR Laser Tissue Damage

机译：近红外激光组织损伤中的色素沉着

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摘要

Damage from femtosecond mode-locked laser exposure (total exposure times longer than 20 microseconds) is predicted to be mediated by the same thermal mechanism found for continuous wave (CW) laser exposure. Experimentally, this trend holds true when comparing minimum visible lesions (MVL) from 0.25 s mode-locked and CW near-IR exposures in vivo. To further test this hypothesis in an in vitro setting we compared threshold values for cell death at various times post-exposure for mode-locked and CW 810-nm laser exposures. Using an artificially pigmented RPE cell culture system we show that damaging absorption of NIR laser light is directly related to the presence of melanin pigment granules, and that the damage thresholds for mode-locked and CW laser exposures are essentially the same for the pigmented cells. We additionally conclude that the artificially pigmented RPE cell cultures are a reasonable model system for the study of thermal and photomechanical forms of ocular laser tissue damage.
机译：飞秒锁模激光曝光（总曝光时间长于20微秒）所造成的损害预计将由对连续波（CW）激光曝光所发现的相同热机制来介导。实验上，当比较0.25 s锁模和CW近红外暴露在体内的最小可见病变（MVL）时，这种趋势适用。为了在体外环境中进一步检验该假设，我们比较了锁模和连续波810 nm激光曝光后不同时间的细胞死亡阈值。使用人工色素的RPE细胞培养系统，我们显示NIR激光的有害吸收与黑色素色素颗粒的存在直接相关，并且锁模和CW激光照射的损伤阈值对于色素细胞基本相同。我们还得出结论，人工色素RPE细胞培养物是研究热和光机械形式的眼部激光组织损伤的合理模型系统。

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