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首页> 外文会议>Conference on Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III Jan 26-27, 2003 San Jose, California, USA >Nonlinear optical characterization of retinal molecules
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Nonlinear optical characterization of retinal molecules

机译：视网膜分子的非线性光学表征

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The measurements on the nonlinear absorption coefficient for the whole retina and separated molecular components have been determined using open-aperture z-scan. Our recent retinal damage studies have shown that the threshold for retinal damage decreases below one nanosecond. Laser-induced breakdown has been implicated in the threshold-level mechanism for damage. The threshold is reduced below 100 fs, where LIB is the damage mechanism. Our hypothesis for this experiment is that non-linear optical properties of the constituents of the retina will affect the absorption coefficient of the retina for ultrashort pulse laser exposure and lower the retinal damage threshold for these exposures by lowering the laser-induced breakdown threshold in the tissues. This suggests that nonlinear absorption effects should be considered in the analysis of any data that relate energy deposition rates from laser exposures in tissue to thermal or photomechanical damage mechanisms for cell death. We describe the impact of these measurements on retinal damage thresholds and damage mechanisms for various pulse regimes.
机译：已使用开孔z扫描确定了整个视网膜和分离的分子成分的非线性吸收系数的测量值。我们最近的视网膜损伤研究表明，视网膜损伤的阈值降低到一纳秒以下。激光引起的击穿与损伤的阈值水平机制有关。阈值降低到100 fs以下，其中LIB是损坏机制。我们对该实验的假设是，视网膜成分的非线性光学特性将影响超短脉冲激光暴露时视网膜的吸收系数，并通过降低激光诱导的击穿阈值来降低这些暴露的视网膜损伤阈值。组织。这表明，在分析任何将组织中激光暴露的能量沉积速率与细胞死亡的热或光机械损伤机制相关的数据时，应考虑非线性吸收效应。我们描述了这些测量对各种脉冲方式对视网膜损伤阈值和损伤机制的影响。

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