Laser-induced macular holes demonstrate impaired choroidal perfusion

机译：激光诱发的黄斑裂孔显示脉络膜灌注受损

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Choroidal perfusion was evaluated following the creation of a laser induced macular hole in a nonhuman primate model. Two Rhesus monkeys underwent macular exposures delivered by a Q-switched Nd: YAG laser. The lesions were evaluated with fluorescein angiography and indocyanine green (ICG) angiography . Each lesion produced vitreous hemorrhage and progressed to a full thickness macular hole. ICG angiography revealed no perfusion of the choriocapillaris beneath the lesion centers. Histopathologic evaluation showed replacement of the choriocapillaris with fibroblasts and connective tissue. Nd:YAG, laser-induced macular holes result in long term impairment of choroidal perfusion at the base of the hole due to choroidal scarring and obliteration of the choriocapillaris.

机译：在非人灵长类动物模型中产生激光诱导的黄斑裂孔后，评估脉络膜灌注。两只恒河猴通过调Q的Nd：YAG激光进行黄斑暴露。通过荧光素血管造影和吲哚菁绿（ICG）血管造影评估病变。每个病变都会引起玻璃体出血，并发展为全厚度的黄斑裂孔。 ICG血管造影显示在病变中心下方未灌注脉络膜毛细血管。组织病理学评估显示成纤维细胞和结缔组织取代脉络膜毛细血管。 Nd：YAG激光诱导的黄斑裂孔会导致脉络膜瘢痕形成和脉络膜毛细血管闭塞，从而长期损害孔底的脉络膜灌注。

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《Conference on Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III Jan 26-27, 2003 San Jose, California, USA》|2003年|p.17-26|共10页
会议地点 San Jose CA(US)
作者
Jeremiah Brown; Jr; Ronald D. Allen; Harry Zwick; Steven T. Schuschereba; David J. Lund; Bruce E. Stuck;
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作者单位

United States Army Medical Research Detachment-Walter Reed Army Institute of Research, 7965 Dave Erwin Drive, Brooks AFB, Texas 78235;

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会议组织
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
choriocapillaris; fluorescein; indocyanine green; laser injury; macular hole; Q-switch Nd:YAG laser;

机译：脉络膜毛细血管；荧光素；吲哚菁绿；激光损伤；黄斑裂孔；调Q开关Nd：YAG激光;

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1. Laser-induced macular holes demonstrate impaired choroidal perfusion. [J] . Allen RD, Brown J Jr, Zwick H, Retina . 2004,第1期

机译：激光诱发的黄斑裂孔显示脉络膜灌注受损。
2. The evaluation and correlation of subfoveal choroidal thickness and macular hole apical and basal diameters with enhanced depth imaging optical coherence tomography in patients with idiopathic macular hole [J] . Ali Keles, Mehmet Citirik, Cagri Ilhan, Eye Reports . 2020,第1期

机译：特发性黄斑孔患者具有增强深度成像光学相干断层扫描的子胚肠脉络膜厚度和黄斑孔顶部和基底直径的评价与相关性
3. Recurrence of Macular Hole Retinal Detachment after Intravitreal Ranibizumab Injection for the Treatment of Choroidal Neovascularization from the Remaining Macular Hole Edge [J] . Azumi A., Honda S., Imai H., Case Reports in Ophthalmology . 2012,第3期

机译：玻璃体腔注射雷珠单抗治疗剩余黄斑孔边缘的脉络膜新生血管后黄斑孔视网膜脱离的复发
4. Laser-induced macular holes demonstrate impaired chorodial perfusion [C] . Jeremiah Brown Jr, Ronald D. Allen, Harry Zwick, Conference on laser and noncoherent light ocular effects: Epidemiology, prevention, and treatment . 2003

机译：激光诱导的黄斑孔表现出抗湿润灌注受损
5. Clinical Features of Treated and Untreated Type 1 Idiopathic Macular Telangiectasia Without the Occurrence of Secondary Choroidal Neovascularization Followed for 2 Years in Japanese Patients [D] . 逢坂理恵 2019

机译：在日本患者中治疗和未治疗的1型特发性黄斑部毛细血管扩张症的临床特征为继发性脉络膜新血管形成，随访2年
6. Recurrence of Macular Hole Retinal Detachment after Intravitreal Ranibizumab Injection for the Treatment of Choroidal Neovascularization from the Remaining Macular Hole Edge [O] . Keiko Otsuka, Hisanori Imai, Tsuyoshi Shimoyama, 2012

机译：玻璃体腔注射雷珠单抗治疗剩余黄斑孔边缘的脉络膜新生血管后黄斑孔视网膜脱离的复发
7. Recurrence of Macular Hole Retinal Detachment after Intravitreal Ranibizumab Injection for the Treatment of Choroidal Neovascularization from the Remaining Macular Hole Edge [O] . Otsuka Keiko, Imai Hisanori, Shimoyama Tsuyoshi, 2012

机译：玻璃体腔注射雷珠单抗治疗剩余黄斑孔边缘的脉络膜新生血管后黄斑孔视网膜脱离的复发

Laser-induced macular holes demonstrate impaired choroidal perfusion

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