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首页> 外文会议>Conference on Laser and Noncoherent Light Ocular Effects: Epidemiology, Prevention, and Treatment III Jan 26-27, 2003 San Jose, California, USA >Chromosome mutations and tissue regeneration in the cornea after the UV laser irradiation
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Chromosome mutations and tissue regeneration in the cornea after the UV laser irradiation

机译：紫外线激光照射后角膜的染色体突变和组织再生

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摘要

In present paper the findings on chromosome mutations, the nature of damage and the repair of the cornea tissue after UV irradiation by excimer lasers at 193, 223 and 248 nm were made. Structural mutations induced by short-pulses UV irradiation were shown to be similar to spontaneous ones by the type, time of formation in the mitotic cycle and location of acentrics. Ten hours after irradiation of the cornea with doses of 0,09 to 1,5 J/cm~2 the incidence of cells with chromosome aberrations increased linearly with dose and amounted to 11,7% at 248 nm, 5,5% at 223 nm and 2,6% at 193 nm per 1 J/cm~2. No induced chromosome aberrations occurred 72 hour following irradiation. Within the dose range from 3,0 to 18 J/cm~2 the cytogenesis effect of radiation was less manifest than that with the doses mentioned above, the frequency of chromosome aberrations being independent of either radiation wavelength or radiation dose and amounted of 2,5 to 3,0%. Thus, large doses of powerful short-pulse UV radiation are safe according to the structural mutation criterion.
机译：本文对准分子激光在193、223和248 nm紫外线照射后的染色体突变，损伤性质和角膜组织修复进行了研究。短脉冲紫外线辐射诱导的结构突变在有丝分裂周期的类型，形成时间和无心轴的位置方面显示出与自发突变相似。剂量为0.09至1.5 J / cm〜2的角膜照射十小时后，染色体畸变的细胞的发生率随剂量线性增加，在248 nm处达到11.7％，在223 nm处达到5.5％每1 J / cm〜2在193 nm处的平均光吸收强度为2.5 nm和2.6％。照射后72小时未发生诱导的染色体畸变。在3.0至18 J / cm〜2的剂量范围内，辐射的细胞发生效应不如上述剂量明显，染色体畸变的频率与辐射波长或辐射剂量无关，为2， 5至3.0％。因此，根据结构突变准则，大剂量的强短脉冲紫外线辐射是安全的。

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