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首页> 外文会议>Conference on Laser-Tissue Interaction XI: Photochemical, Photothermal, and Photomechanical 22-27 January 2000 San Jose, USA >Myocardium tissue ablation with nanosecond, ultraviolet pulses: In-vitro study with porcine myocardium tissues
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Myocardium tissue ablation with nanosecond, ultraviolet pulses: In-vitro study with porcine myocardium tissues

机译：纳秒级紫外线脉冲消融心肌组织：猪心肌组织的体外研究

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摘要

To investigate the optimum irradiation conditions for the transmyocardial laser revascularization (TMLR), ablation characteristics have been explored in vitro with porcine myocardium tissues. With a nanosecond optical parametric oscillator (OPO), the ablation depth and the thickness of thermally damaged tissue were measured at a constant peak intensity or fluence in the ultraviolet spectral region of 230 - 400 nm. It was found that at a peak intensity of 80 MW/cm~2, the ablation depth steeply increased for < 300 nm, while the thickness of thermally damaged tissue decreased with decreasing the wavelength. To understand the wavelength dependence of the ablation characteristics, we measured the optical properties of the tissue. This showed that the total attenuation coefficient largely increased with decreasing the wavelength for < 300 nm. Therefore, it is considered that at the shorter wavelengths the optical energy density deposited in the tissue would be high enough to ablate the whole region of the light-penetrated tisuue. However, the wavelength dependence might be changed at some higher intensities or fluences. But our experiment using the 3rd and 4th of a Q-switched Nd:YAG laser, the shorter wavelength (266 nm) still gave the deeper ablation for up to 2-5 J/cm~2. The influence of photomechanical effects on the ablation mechanism is also discussed.
机译：为了研究跨心肌激光血管重建术（TMLR）的最佳照射条件，已在体外探索猪心肌组织的消融特性。使用纳秒级光学参量振荡器（OPO），在230-400 nm的紫外光谱区域中以恒定的峰强度或注量量度了烧蚀深度和热损伤组织的厚度。发现在峰值强度为80 MW / cm〜2时，<300 nm处的消融深度急剧增加，而热损伤组织的厚度随着波长的减小而减小。为了了解消融特征的波长依赖性，我们测量了组织的光学性质。这表明，总衰减系数随着<300 nm波长的减小而大大增加。因此，认为在较短的波长下，沉积在组织中的光能密度将足够高，以消融光穿透组织的整个区域。但是，波长依赖性可能会在更高的强度或注量下发生变化。但是我们的实验使用了Q开关Nd：YAG激光器的第3和第4波长，较短的波长（266 nm）仍能提供更深的烧蚀，最高可达2-5 J / cm〜2。还讨论了光机械效应对消融机制的影响。

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