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首页> 外文会议>Conference on Medical Imaging 2008: Imaging Processing; 20080217-19; San Diego,CA(US) >A Variational Method for Automatic Localization of the most Pathological ROI in the Knee Cartilage
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A Variational Method for Automatic Localization of the most Pathological ROI in the Knee Cartilage

机译：自动定位膝关节软骨中最病态ROI的变体方法

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摘要

Osteoarthritis (OA) is a degenerative joint disease characterized by degradation of the articular cartilage, and is a major cause of disability. At present, there is no cure for OA and currently available treatments are directed towards relief of symptoms. Recently it was shown that cartilage homogeneity visualized by MRI and representing the biochemical changes undergoing in the cartilage is a potential marker for early detection of knee OA. In this paper based on homogeneity we present an automatic technique, embedded in a variational framework, for localization of a region of interest in the knee cartilage that best indicates where the pathology of the disease is dominant. The technique is evaluated on 283 knee MR scans. We show that OA affects certain areas of the cartilage more distinctly, and these are more towards the peripheral region of the cartilage. We propose that this region in the cartilage corresponds anatomically to the area covered by the meniscus in healthy subjects. This finding may provide valuable clues in the pathology and the etiology of OA and thereby may improve treatment efficacy. Moreover our method is generic and may be applied to other organs as well.
机译：骨关节炎（OA）是一种以关节软骨退化为特征的变性关节疾病，是导致残疾的主要原因。目前，尚无OA的治愈方法，并且目前可用的治疗旨在缓解症状。最近显示，通过MRI可视化并表示软骨中发生的生化变化的软骨同质性是早期检测膝OA的潜在标志。在基于同质性的本文中，我们提出了一种自动技术，该技术嵌入变化框架中，用于对膝盖软骨中感兴趣的区域进行定位，从而最好地表明该疾病的病理部位占主导地位。该技术在283膝MR扫描中得到评估。我们表明，OA对软骨的某些区域的影响更为明显，而这些区域更多地向软骨的周边区域发展。我们建议，在健康受试者中，软骨中的该区域在解剖学上对应于半月板覆盖的区域。该发现可以提供关于OA的病理学和病因的有价值的线索，从而可以改善治疗效果。而且，我们的方法是通用的，也可以应用于其他器官。

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