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首页> 外文会议>Conference on Multiphoton Microscopy in the Biomedical Sciences IV; 20040125-20040127; San Jose,CA; US >Two-photon absorption induced drug delivery from polymers for medical applications
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Two-photon absorption induced drug delivery from polymers for medical applications

机译：两光子吸收诱导聚合物从医用药物中释放出来

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摘要

Novel polymeric materials carrying a drug depot have been developed which are suitable for fabrication of photochemically modulated drug delivery devices. In order to avoid uncontrolled drug release the drug is covalently attached to the polymer backbone using a photo-active linker. Controlled drug release from the polymer can be accomplished either via single-photon excitation or by two-photon absorption (TPA). In particular the second possibility is of interest for applications where exposure to day light or UV light may not be omitted. One example are polymeric intraocular lenses (IOL), which are implanted instead of the opaque natural lens during cataract surgery. Secondary cataract formation is quite often observed after implantation of polymeric IOLs. In this study the well known cell toxic agent 5-fluorouracil (5FU) attached to a methylmethacrylate-based polymer was investigated as an IOL which can upon photochemical excitation release 5FU in order to treat or to prevent secondary cataract formation. The photochemical cleavage of the linker molecule was analyzed with single- and two-photon excitation. UV/VIS spectroscopy and HPLC analysis confirmed the release of 5FU form the polymer backbone. The diffusion of the drug precursor out from the polymer as well as the hydrolysis of the drug precursor which leads to 5FU formation were investigated in vitro.
机译：已经开发了携带药物仓库的新型聚合物材料，其适合于制造光化学调制的药物递送装置。为了避免药物的不受控制的释放，使用光敏接头将药物共价附于聚合物主链。可以通过单光子激发或通过双光子吸收（TPA）实现药物从聚合物中的受控释放。特别地，第二种可能性是对于可能不忽略暴露于日光或紫外线的应用而言是令人感兴趣的。一个例子是聚合物人工晶状体（IOL），其在白内障手术期间代替不透明的天然晶状体被植入。植入人工晶状体后，通常会观察到继发性白内障的形成。在这项研究中，以IOL的形式研究了附着在基于甲基丙烯酸甲酯的聚合物上的众所周知的细胞毒剂5-氟尿嘧啶（5FU），该IOL可以在光化学激发下释放5FU，以治疗或预防继发性白内障。用单光子和双光子激发分析接头分子的光化学裂解。 UV / VIS光谱和HPLC分析证实了5FU从聚合物骨架中释放出来。体外研究了药物前体从聚合物中的扩散以及药物前体的水解（导致5FU形成）。

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