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首页> 外文会议>Conference on Ophthalmic Technologies XIV; 20040124-20040125 and 20040127; San Jose,CA; US >Computational modeling of corneal refractive surgery
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Computational modeling of corneal refractive surgery

机译：角膜屈光手术的计算模型

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摘要

A finite element method was used to study the biomechanical behavior of the cornea and its response to refractive surgery when stiffness inhomogeneities varying with depth are considered. Side-by-side comparisons of different constitutive laws that have been commonly used to model refractive surgery were also performed. To facilitate the comparison, the material property constants were identified from the same experimental data, which were obtained from mechanical tests on corneal strips and membrane inflation experiments. We then validated the resulting model by comparing computed refractive power changes with clinical results. The model developed provides a much more predictable refractive outcome when the stiffness inhomogeneities of the cornea and nonlinearities of the deformations are included in the finite element simulations. Thus, it can be stated that the inhomogeneous model is a more accurate representation of the corneal material properties in order to model the biomechanical effects of refractive surgery. The simulations also revealed that the para-central and peripheral parts of the cornea deformed less in response to pressure loading compared to the central cornea and the limbus. Furthermore, the deformations in response to pressure loading predicted by the non-homogeneous and nonlinear model, showed that the para-central region is mechanically enhanced in the meridional direction. This result is in agreement with the experimentally documented regional differences reported in the literature by other investigators.
机译：当考虑到刚度不均匀性随深度变化时，采用有限元方法研究角膜的生物力学行为及其对屈光手术的反应。还进行了通常用于模拟屈光手术的不同本构关系的并排比较。为了便于比较，从相同的实验数据中确定了材料性能常数，这些数据是通过对角膜条的机械测试和膜膨胀实验获得的。然后，我们通过将计算得到的屈光力变化与临床结果进行比较来验证结果模型。当角膜的刚度不均匀性和变形的非线性包括在有限元模拟中时，开发的模型可以提供更可预测的屈光结果。因此，可以说，不均匀模型是角膜材料特性的更准确表示，以便对屈光手术的生物力学效应进行建模。模拟还显示，与中央角膜和角膜缘相比，角膜的中央部位和周边部分在压力负荷下的变形较小。此外，由非均匀和非线性模型预测的响应于压力载荷的变形表明，在中央子午线区域在子午方向上得到了机械增强。该结果与其他研究者在文献中报道的实验记录的区域差异一致。

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