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首页> 外文会议>Conference on Optical Diagnostics of Living Cells Ⅴ, Jan 23-25, 2002, San Jose, USA >Photoacoustic tweezers
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Photoacoustic tweezers

机译：光声镊子

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The goal of this study was to develop a new approach to manipulating biological and nonbiological objects in liquid or gas, with a focus on living cells in liquid. This approach is based on laser-generated thermal and pressure gradients in the medium surrounding an object, which create forces of different origins acting on the object. In general, depending on the spatial geometry of these forces, particles can be trapped (symmetrical forces) or moved in desired directions (asymmetrical forces). Comparison of the different mechanisms for creating photothermal (PT) and photoacoustic (PA) gradients and their roles in manipulating particles are considered, including heating through absorption, optical breakdown, and plasma and bubble formation. The PA and PT gradients lead in turn to the formation of many physical phenomena, some of which may be important for particle movement, separation, sorting, and trapping. Among these phenomena are fast thermal expansion, acoustic radiation pressure, directed thermal convection, acoustic streamers, laser-induced jets, laser-generated high-frequency focused ultrasound, radiometric forces, nonisotropic Brownian motion, and asymmetry in thermal effects of irradiated particles, including thermal expansion, evaporation, ablation, and infrared (IR) radiation. Different phenomena are shown to play dominant roles in the manipulation of particles, depending on the particle or cell type, parameters of the surrounding medium, laser energy, and the beam's shape or geometry. The optical systems for particle manipulation using different laser spot shapes and geometry (i.e., circular, linear, crescent, or multispot and ring configurations) are presented. The advantages and limitations of this new member of the family of different "tweezers" are discussed.
机译：这项研究的目的是开发一种处理液体或气体中生物和非生物物体的新方法，重点是液体中的活细胞。这种方法是基于激光在物体周围的介质中生成的热梯度和压力梯度，这些梯度会产生作用在物体上的不同来源的力。通常，根据这些力的空间几何形状，粒子可能会被捕获（对称力）或沿所需方向移动（不对称力）。考虑了创建光热（PT）和光声（PA）梯度的不同机制及其在操纵粒子中的作用的比较，包括通过吸收加热，光学击穿以及等离子体和气泡的形成。 PA和PT梯度依次导致许多物理现象的形成，其中某些物理现象可能对粒子的移动，分离，分选和捕集很重要。这些现象包括快速的热膨胀，声辐射压力，定向热对流，声流，激光诱导的射流，激光产生的高频聚焦超声，辐射力，非等向布朗运动以及被辐射粒子的热效应的不对称性，包括热膨胀，蒸发，烧蚀和红外（IR）辐射。根据粒子或细胞的类型，周围介质的参数，激光能量以及光束的形状或几何形状，显示出不同的现象在粒子的操纵中起主要作用。提出了使用不同激光点形状和几何形状（即圆形，线性，新月形或多点和环形结构）进行粒子操纵的光学系统。讨论了这种“镊子”家族的新成员的优缺点。

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