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首页> 外文会议>Conference on Optical Diagnostics and Sensing IV; 20040127; San Jose,CA; US >Raman, Mid and Nir FTIR absorption spectra of breast cancer reveal a good diagnosis tool
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Raman, Mid and Nir FTIR absorption spectra of breast cancer reveal a good diagnosis tool

机译：乳腺癌的拉曼，中和近红外FTIR吸收光谱揭示了良好的诊断工具

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Fourier transform Raman and IR spectra are examined for malignant and normal breast tissues. Aside from individual differences that result in normal variations in lipids and glycogen, a clear distinction between normal and malignant tissues can be observed. MIR absorption spectra was observed using FTIR- Raman Spectrometer technique working in the regions Mir, Nir, Fir as well as VIS. Also the system can record Raman Scattering in the region from -2000 to 5600 cm-1 using Nd-Yag laser source of power 1500 mW. The comparison of Mid FTIR spectra from different samples of breast tumors with normal spectra reveals very important features that can be useful as diagnostic techniques. An absorption line centered at 3303 cm~(-1) varies considerably and depends on the nature of the lesion, lipids and proteins composition. The ratio (I_(3443)/I_(4352)) has an average value of 2.4+-0.3 for normal tissues while in the case of malignant tissues its average is 4.5+-2.8. Abroad absorption band was observed in some malignant cases between 2800- 3750 cm~(-1). A good shaped lines at 4259 and 4332 cm~(-1) is clear in normal spectra, these lines tend to disappear in malignant cases. A normally existing line at 3470 cm~(-1) increases considerably in malignant cases . When the tumor is not yet malignant it seems that the lines at 4259 and 4320 cm~(-1) disappears first rapidly. As the tumor turns to be malignant, the band at 3470 cm~(-1) increases and a new well defined band at 5167 cm~(-1) appears. Moreover, Raman spectra showed the appearance of a new band at 2900 cm~(-1) in the case of malignancy. While in normal breast samples this band didn't show up. Data obtained in the NIR region confirms our observation in the MIR region.
机译：检查傅立叶变换拉曼光谱和红外光谱，检查恶性和正常乳腺组织。除了导致脂质和糖原正常变异的个体差异外，还可以观察到正常组织与恶性组织之间的明显区别。使用FTIR-拉曼光谱仪技术在Mir，Nir，Fir和VIS区域工作，观察到MIR吸收光谱。该系统还可以使用功率为1500 mW的Nd-Yag激光源记录从-2000到5600 cm-1的拉曼散射。来自不同乳腺肿瘤样品的Mid FTIR光谱与正常光谱的比较显示出非常重要的功能，可以用作诊断技术。以3303 cm-1（-1）为中心的吸收线变化很大，并取决于病变的性质，脂质和蛋白质组成。正常组织的比率（I_（3443）/ I_（4352））的平均值为2.4 + -0.3，而在恶性组织的情况下，平均值为4.5 + -2.8。在某些恶性病例中，在2800-3750 cm〜（-1）之间观察到了国外吸收带。在正常光谱中，在4259和4332 cm〜（-1）处有一条良好的形状清晰的线条，在恶性情况下这些线条倾向于消失。在恶性情况下，正常存在的3470 cm〜（-1）线会大大增加。当肿瘤尚未恶变时，似乎在4259和4320 cm〜（-1）处的线首先迅速消失。随着肿瘤变成恶性肿瘤，在3470 cm〜（-1）处的条带增加，并在5167 cm〜（-1）处出现新的清晰的条带。此外，在恶性肿瘤的情况下，拉曼光谱显示在2900cm〜（-1）处出现了新的条带。在正常的乳房样本中，该条带没有出现。在NIR区域获得的数据证实了我们在MIR区域的观察。

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