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首页> 外文会议>Conference on Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XII Jan 25-26, 28, 2003 San Jose, California, USA >CLINICAL STUDIES OF PHOTODYNAMIC THERAPY FOR MALIGNANT BRAIN TUMORS: FACIAL NERVE PALSY AFTER TEMPORAL FOSSA PHOTOILLUMINATION
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CLINICAL STUDIES OF PHOTODYNAMIC THERAPY FOR MALIGNANT BRAIN TUMORS: FACIAL NERVE PALSY AFTER TEMPORAL FOSSA PHOTOILLUMINATION

机译：光敏性脑肿瘤光动力疗法的临床研究：颞叶光照射后的面神经麻痹

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摘要

In two randomized prospective studies of brain tumor PDT more than 180 patients have been accrued. At the Toronto site we recognized two patients who developed a lower motor neuron [LMN] facial paralysis in the week following the PDT treatment. In both cases a temporal lobectomy was undertaken and the residual tumor cavity was photo-illuminated. The surface illuminated included the temporal fossa floor, thus potentially exposing the facial nerve to the effect of PDT. The number of frontal, temporal, parietal, and occipital tumors in this cohort was 39, 24, 12 and 4, respectively. Of the 24 temporal tumors 18 were randomized to Photofrin-PDT. Of these 18 a temporal lobectomy was carried out exposing the middle fossa floor as part of the tumor resection. In two of the 10 patients where the lobectomy was carried out and the fossa floor was exposed to light there occurred a postoperative facial palsy. Both patients recovered facial nerve function in 6 and 12 weeks, respectively. 46 J/cm~2 were used in the former and 130 J/cm~2 in the latter.
机译：在两项关于脑肿瘤PDT的随机前瞻性研究中，已有180多例患者入选。在多伦多站点，我们确认了两名患者在PDT治疗后一周出现了下运动神经元[LMN]面神经麻痹。在这两种情况下，均进行了颞叶切除术并用光照射了残留的肿瘤腔。被照亮的表面包括颞窝底，因此可能使面神经暴露于PDT的作用。在该队列中，额部，颞部，顶叶和枕部肿瘤的数量分别为39、24、12和4。在24个颞部肿瘤中，有18个被随机分配到Photofrin-PDT。在这18例中，作为肿瘤切除术的一部分，进行了颞叶切除术，暴露了中窝底部。在10例行肺叶切除术并暴露于窝底的患者中，有2例发生了术后面神经麻痹。两名患者分别在6周和12周内恢复了面神经功能。前者使用46 J / cm〜2，后者使用130 J / cm〜2。

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