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首页> 外文会议>Conference on Optical Technologies in Biophysics and Medicine IV; Oct 1-4, 2002; Saratov, Russia >Optical Coherence Tomography: Light Scattering Reduction and Imaging Enhancement
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Optical Coherence Tomography: Light Scattering Reduction and Imaging Enhancement

机译：光学相干断层扫描：减少光散射和增强成像

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摘要

The highly scattering nature of human tissue limits light penetration depth in the near infrared range, which prevents the deeper microstructures from imaging. In order to enhance the imaging depth for the current high resolution optical imaging techniques, the light scattering in tissue must be reduced. This presentation demonstrates that the light scattering of tissue can be effectively reduced by the topical applications of the biocompatible chemical agents. In this study the propylene glycol, a biocompatible osmotic compound was chosen for the demonstration. The experiments were performed in vitro and in vivo by the use of the optical coherence tomography system. The results clearly show that the OCT imaging depth and contrast are dramatically improved after the topical applications of propylene glycol solution. Such improvement was discussed on the basis of refractive index matching environment created by the chemical agents, which effectively reduces the light scattering of tissue. Rayleigh-Gans approximation of light scattering was also used to show theoretically how the increase of refractive index of background medium would have effect on the reduced scattering coefficient of tissue. The theoretical and experimental results were qualitatively consistent.
机译：人体组织的高度散射性将光的穿透深度限制在近红外范围内，从而阻止了更深的微结构成像。为了增强当前高分辨率光学成像技术的成像深度，必须减少组织中的光散射。该介绍表明，通过生物相容性化学剂的局部应用可以有效地减少组织的光散射。在这项研究中，选择了丙二醇（一种生物相容性渗透化合物）进行演示。通过使用光学相干断层扫描系统在体外和体内进行实验。结果清楚地表明，局部应用丙二醇溶液后，OCT成像深度和对比度得到了显着改善。在化学试剂产生的折射率匹配环境的基础上讨论了这种改进，该环境有效地减少了组织的光散射。在理论上，还使用光散射的瑞利-甘斯（Rayleigh-Gans）近似值来说明背景介质折射率的增加如何对组织的散射系数降低产生影响。理论和实验结果在质量上是一致的。

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