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首页> 外文会议>Conference on Optical Technologies in Biophysics and Medicine IV; Oct 1-4, 2002; Saratov, Russia >The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis urinary bladder cancer
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The effects of visual fluorescence marking induced by 5-aminolevulinic acid for endoscopic diagnosis urinary bladder cancer

机译：5-氨基乙酰丙酸诱导的可视荧光标记在内镜诊断膀胱癌中的作用

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摘要

During cystoscopy procedure, fluorescence diagnostics induced by 5-ALA improves visual detection of the bladder cancer. Macroscopic ALA-fluorescence allows visualizing of small flat tumors, carcinoma in situ, true neoplasm margins and dysplasias of the bladder. Following ALA instillation, cystoscopy has been performed under both standard and blue light illumination. Totally, 153 biopsies have been carried out at 53 patients with suspicion of bladder cancer. The results were compared to ALA-fluorescence data. In 13% of the patients, bladder cancer and dysplasia were found out in addition, due to red fluorescence. The sensitivity and specificity of ALA-fluorescence technique aggregated 96% and 52 % respectively. The sensitivity and the specificity of 5-ALA- fluorescent detection exceeded standard endoscopy under white light on 20%. The new method does not exclude a false positive and a false negative fluorescent luminescence. The ALA-based fluorescence detection system enhances the diagnosis of malignant/dysplastic bladder lesions significantly.
机译：在膀胱镜检查过程中，由5-ALA诱导的荧光诊断可改善膀胱癌的视觉检测。宏观ALA荧光可以观察到小的扁平肿瘤，原位癌，真正的肿瘤边缘和膀胱发育异常。滴注ALA后，已在标准和蓝光照明下进行了膀胱镜检查。总共对53名怀疑患有膀胱癌的患者进行了153次活检。将结果与ALA荧光数据进行比较。在13％的患者中，由于红色荧光，还发现了膀胱癌和发育不良。 ALA荧光技术的敏感性和特异性分别为96％和52％。 5-ALA-荧光检测的灵敏度和特异性在白光下20％时超过了标准内窥镜检查。新方法不排除假阳性和假阴性荧光发光。基于ALA的荧光检测系统显着增强了恶性/增生性膀胱病变的诊断。

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