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首页> 外文会议>Conference on Optical Technologies in Biophysics and Medicine IV; Oct 1-4, 2002; Saratov, Russia >Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartment evoked by sciatic nerve stimulation in rat somatosensory cortex
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Spatio-temporal characteristics of cerebral blood volume changes in different microvascular compartment evoked by sciatic nerve stimulation in rat somatosensory cortex

机译：坐骨神经刺激诱发的大鼠体感皮层不同微血管区的脑血容量变化的时空特征

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摘要

The spatio-temporal characteristics of changes in cerebral blood volume associated with neuronal activity were investigated in the hindlimb somatosensory cortex of α -chloralose/urethan anesthetized rats (n=10) with optical imaging at 570nm through a thinned skull. Activation of cortex was carried out by electrical stimulation of the contralateral sciatic nerve with 5Hz, 0.3V pulses (0.5ms) for duration of 2s. The stimulation evoked a monophasic optical reflectance decrease at cortical parenchyma and arteries sites rapidly after the onset of stimulation, whereas no similar response was observed at vein compartments. The optical signal changes reached 10% of the peak response 0.70 +- 0.32s after stimulation onset and no significant time lag in this 10% start latency time was observed between the response at cortical parenchyma and arteries compartments. The evoked optical reflectance decrease reached the peak (0.25% +- 0.047%) 2.66+- 0.61s after the stimulus onset at parenchyma site, 0.40+- 0.20s earlier (P<0.05) than that at arteries site (0.50% +- 0.068% 3.06 +- 0.70s). Variable location within the cortical parenchyma and arteries compartment themselves didn't affect the temporal characteristics of the evoked signal significantly. These results suggest that the sciatic nerve stimulation evokes a local blood volume increase at both capillaries (cortical parenchyma) and arterioles rapidly after the stimulus onset but the evoked blood volume increase in capillaries could not be entirely accounted for by the dilation of arterioles.
机译：研究了α-氯藻糖/尿烷麻醉的大鼠（n = 10）的后肢体感皮层中570纳米厚度的光学成像，研究了与神经元活动相关的脑血容量变化的时空特征。皮质的激活是通过以5Hz，0.3V脉冲（0.5ms）电刺激对侧坐骨神经持续2s来进行的。刺激开始后，刺激在皮质实质和动脉部位引起单相光反射率降低，而在静脉腔未观察到类似的反应。刺激开始后，光信号变化达到峰值响应0.70±0.32s的10％，在皮层实质和动脉腔室之间的响应之间，在这10％的启动等待时间中未观察到明显的时间滞后。在实质部位刺激发生后，诱发的光反射率下降达到峰值（0.25％+-0.047％）2.66 +-0.61s，比动脉部位（0.50％+-）提前0.40 +-0.20s（P <0.05）。 0.068％3.06±-0.70s）。皮层薄壁组织和动脉腔内的位置不可变，不会明显影响诱发信号的时间特性。这些结果表明，在刺激开始后，坐骨神经刺激引起毛细血管（皮层实质）和小动脉的局部血容量迅速增加，但是毛细血管的扩张不能完全解释毛细血管诱发的血容量增加。

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