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首页> 外文会议>Conference on Optical Technologies in Biophysics and Medicine IV; Oct 1-4, 2002; Saratov, Russia >Large Scale and Global Features of Complex Genomic Signals
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Large Scale and Global Features of Complex Genomic Signals

机译：复杂基因组信号的大规模和全球性特征

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摘要

The paper briefly reviews the methodology of the symbolic nucleic sequence conversion into genomic signals and presents large scale and global features of the resulting genomic signals. Whole chromosomes or whole genomes are converted into complex genomic signals and phase analysis is performed. The phase, cumulated phase and unwrapped phase of genomic signals are studied as tools for revealing important features of to the first and second order statistics of nucleotide distribution along DNA strands. It is shown that the unwrapped phase displays an almost linear variation along whole chromosomes. The property holds for all the investigated genomes, being shared by both prokaryotes and eukaryotes, while the magnitude and sign of the unwrapped phase slope is specific for each taxon and chromosome. The comparison between the behavior of the cumulated phase and of the unwrapped phase across the putative origins and termini of the replichores suggests a model of the 'patchy' structure of the chromosomes.
机译：本文简要回顾了将符号核酸序列转换为基因组信号的方法，并介绍了所得基因组信号的大规模和全局特征。将整个染色体或整个基因组转换为复杂的基因组信号，并进行相分析。研究基因组信号的相位，累积相位和未包裹相位，作为揭示沿DNA链的核苷酸分布的一阶和二阶统计的重要特征的工具。结果表明，展开的相沿整个染色体显示出几乎线性的变化。该特性适用于所有被研究的基因组，由原核生物和真核生物共享，而未包裹的相坡度的大小和符号对于每个分类群和染色体都是特定的。跨越假定的起点和终点的累积阶段和未包裹阶段的行为之间的比较表明了染色体的“斑点”结构模型。

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