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首页> 外文会议>Conference on Optics in Health Care and Biomedical Optics; 20071112-15; Beijing(CN) >Progress on noninvasive and minimally invasive methods on transcutaneous blood glucose sensing
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Progress on noninvasive and minimally invasive methods on transcutaneous blood glucose sensing

机译：经皮血糖传感的无创和微创方法研究进展

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Noninvasive and minimally invasive blood glucose sensing is one of most interesting research fields. For the noninvasive measurement using near-infrared spectroscopy, the optical signal was impaired by the uncertain physiological noise and systematical drift. A floating reference method by differentially processing two signals from reference point and measuring point was used to deal with these uncertain noises. For the minimally invasive measurement, interstitial fluid extracted by ultrasound and vacuum is investigated. Low-frequency ultrasound was applied to enhance the skin permeability to interstitial fluid by disrupting the stratum corneum lipid bilayers. In this paper, a kind of protein absorbing the glucose specifically called D-galactose/D-glucose Binding Protein (GGBP) was introduced to construct a novel surface plasmon resonance (SPR) measuring system. By immobilizing GGBP onto the surface of the SPR sensor, a new detecting system for glucose testing in mixed solution was developed. The experimental result indicated that, the SPR system succeeded in distinguishing glucose resolution of 0. 1 mg/L, and had linear relationship between 0.5 mg/L and 5 mg/L.
机译：无创和微创血糖传感是最有趣的研究领域之一。对于使用近红外光谱的无创测量，光信号受到不确定的生理噪声和系统漂移的影响。浮动参考方法通过对来自参考点和测量点的两个信号进行差分处理来处理这些不确定的噪声。对于微创测量，研究了超声和真空提取的组织液。低频超声通过破坏角质层脂质双层来增强皮肤对组织液的渗透性。本文介绍了一种专门吸收葡萄糖的蛋白质，称为D-半乳糖/ D-葡萄糖结合蛋白（GGBP），以构建新型的表面等离振子共振（SPR）测量系统。通过将GGBP固定在SPR传感器的表面上，开发了一种用于检测混合溶液中葡萄糖的新检测系统。实验结果表明，SPR系统成功地将葡萄糖分辨率分辨为0. 1 mg / L，并且在0.5 mg / L和5 mg / L之间具有线性关系。

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