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首页> 外文会议>Conference on Photon Migration and Diffuse - Light Imaging; Jun 22-23, 2003; Munich, Germany >In vivo quantitative near-infrared spectroscopy in skeletal muscle and bone during rest and isometric exercise
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In vivo quantitative near-infrared spectroscopy in skeletal muscle and bone during rest and isometric exercise

机译：静息和等距运动期间骨骼肌和骨骼的体内定量近红外光谱

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In this study quantitative near-infrared-spectroscopy (MRS) was investigated as a potential tool to measure local O_2 consumption (mVO_2) in human bone (tibia) in comparison with muscle (musculus tibialis anterior). Both tissues were examined at rest and during 80% maximum voluntary isometric muscle contraction. Fifteen subjects were tested. Local variations in oxy-hemoglobin (O_2Hb), desoxy-hemoglobin (HHb), and total hemoglobin (tHb) were investigated with a continuously operating NIRS system. mVO_2 was determined in phases of applied arterial occlusion. At rest mVO_2 was five times higher in muscle than in bone. However, both mVO_2 values showed a distinct correlation with skin-fold thickness. At rest and only in bone we recorded a periodical variation of O_2Hb. HHb was almost constant. This variation of O_2Hb and the resulting variation in tHb indicated chances in blood volume, which are not compatible with the solid nature of bone. During muscle contraction, mVO_2 in muscle increased about twenty fold. As expected, mVO_2 in bone did not significantly increase during muscle contraction. In conclusion, NIRS was confirmed as a valid method to determine the excess mVO_2 in muscle during contraction. For mVO_2 measurements in bone more sophisticated localization techniques are required to separate the effects derived from bone and skin.
机译：在这项研究中，定量近红外光谱（MRS）被研究为一种潜在的工具，可用来测量人骨（胫骨）与肌肉（胫骨前肌）的O_2消耗量（mVO_2）。在休息时和在最大80％的自发等距肌肉收缩过程中均检查了两个组织。测试了十五名受试者。使用连续运行的NIRS系统研究了氧合血红蛋白（O_2Hb），脱氧血红蛋白（HHb）和总血红蛋白（tHb）的局部变化。 mVO_2是在动脉闭塞阶段确定的。静止时，肌肉中的mVO_2比骨骼中的高五倍。但是，两个mVO_2值均与皮褶厚度有明显的相关性。在静止且仅在骨骼中，我们记录了O_2Hb的周期性变化。 HHb几乎恒定。 O_2Hb的这种变化以及由此导致的tHb的变化表明存在血容量的机会，这与骨骼的坚固性不相容。在肌肉收缩期间，肌肉中的mVO_2增加约20倍。不出所料，肌肉收缩期间骨骼中的mVO_2并未显着增加。总之，NIRS被证实是确定收缩过程中肌肉中过量mVO_2的有效方法。对于骨骼中的mVO_2测量，需要更复杂的定位技术来分离源自骨骼和皮肤的效应。

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