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首页> 外文会议>Conference on Physiology and Function: Methods, Systems, and Applications Feb 16-18, 2003 San Diego, California, USA >Tumor microcirculation during a course of combined chemoradiation in patients with primary rectal carcinoma measured with dynamic T1 mapping
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Tumor microcirculation during a course of combined chemoradiation in patients with primary rectal carcinoma measured with dynamic T1 mapping

机译：动态T1图检测原发性直肠癌患者联合化学放疗过程中的肿瘤微循环

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摘要

A recently introduced dynamic T1 mapping technique was used to investigate changes of tumor microcirculatory parameters in 16 patients with clinically staged T3 primary rectal carcinoma during a course of preoperative combined chemoradiation. For dynamic T1 mapping an ultra-fast snapshot FLASH Tl mapping sequence was implemented on a 1.5T whole body MR scanner. Acquiring a series of T1 maps contrast media (CM) uptake and washout over an examination time of 40 min was monitored. From the obtained series of T1-maps perfusion-indices (PI) were calculated as the ratio of maximum slope of the tumor CM curve and the maximum of the arterial CM curve. Using pathologic classification of the resected tumors after therapy the patient group could be divided into patients with and without response to therapy. It was found that mean pre-therapy PI values of tumors showing therapy-response were significantly lower than for tumors with no therapy-response. In addition a different behavior of PI distributions within tumors for both groups was observed. The presented study indicates that PI values and their distributions within a tumor seem to be of predictive value for therapy outcome of preoperative therapy in patients with primary rectal carcinoma.
机译：最近引入的动态T1定位技术用于研究16例临床分期的T3原发性直肠癌在术前联合化学放疗过程中肿瘤微循环参数的变化。对于动态T1映射，在1.5T全身MR扫描仪上实现了超快快照FLASH T1映射序列。监测在40分钟的检查时间内获得的一系列T1图对比剂（CM）摄取和洗脱。从获得的一系列T1-图中，将灌注指数（PI）计算为肿瘤CM曲线的最大斜率与动脉CM曲线的最大值之比。使用治疗后切除肿瘤的病理学分类，患者组可分为对治疗无反应的患者。发现显示出治疗反应的肿瘤的平均治疗前PI值显着低于无治疗反应的肿瘤。另外，观察到两组中肿瘤内PI分布的不同行为。提出的研究表明，PI值及其在肿瘤中的分布似乎对原发性直肠癌患者术前治疗的治疗结果具有预测价值。

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