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首页> 外文会议>Conference on Single Molecule Spectroscopy and Imaging; 20080119-21; San Jose,CA(US) >Novel Detection Scheme for Optical Biosensing Using Whispering Gallery Modes in Clusters of Dielectric Particles
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Novel Detection Scheme for Optical Biosensing Using Whispering Gallery Modes in Clusters of Dielectric Particles

机译：介电粒子簇中使用耳语画廊模式的光学生物传感检测新方案

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摘要

We present a novel concept for an optical biosensor based on Whispering Gallery Mode (WGM) excitations in clusters of spherical microresonators. WGM are specific optical modes that arise when light is trapped by Total Internal Reflection (TIR) inside of a sphere and circulates close to its circumference. These modes are sensitive to the adsorption of (bio-) molecules onto the resonator surface upon which the WGM spectrum is shifted towards higher wavelengths. Compared to single particles, clusters of microresonators offer the advantage of being more easily detected due to then-higher radiative emission power. Further, the lineshape of the spectra obtained from clusters depends crucially on their composition and therefore may be used as a fingerprint for their identification, e.g., for sensing applications in array formats. Our results demonstrate that clusters of microresonators show the same sensitivity and performance as single spheres. The adsorption of layers of polyelectrolytes and bovine serum albumin (BSA) onto clusters of spheres with 10 μm diameter has been monitored in situ. Depending on the choice of materials, we achieved a mass sensitivity limit of 50 fg, which is about 100 times more sensitive than that of state-of-the-art WGM biosensors.
机译：我们提出了基于耳语画廊模式（WGM）激发的球形微谐振器群集中的光学生物传感器的新概念。 WGM是特定的光学模式，当光被球内部的全内反射（TIR）捕获并在其圆周附近循环时会出现。这些模式对（生物）分子在谐振器表面上的吸附很敏感，WGM光谱在该谐振器表面上移向更高的波长。与单个粒子相比，微谐振器簇的优势在于，由于具有更高的辐射发射功率，因此更易于检测。此外，从簇获得的光谱的线形关键地取决于它们的组成，因此可以用作它们的识别的指纹，例如用于阵列格式的感测应用。我们的结果表明，微谐振器簇显示出与单个球体相同的灵敏度和性能。现场监测了聚电解质层和牛血清白蛋白（BSA）在直径为10μm的球簇上的吸附。根据材料的选择，我们实现了50 fg的质量灵敏度极限，这是最先进的WGM生物传感器的灵敏度的100倍左右。

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