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首页> 外文会议>Conference on Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes; 20080121-22; San Jose,CA(US) >Optical imaging of RNAi-mediated silencing of cancer
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Optical imaging of RNAi-mediated silencing of cancer

机译：RNAi介导的癌症沉默的光学成像

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摘要

RNAi has rapidly become a powerful tool for drug target discovery and validation in an in vitro culture system and, consequently, interest is rapidly growing for extension of its application to in vivo systems, such as animal disease models and human therapeutics. Cancer is one obvious application for RNAi therapeutics, because abnormal gene expression is thought to contribute to the pathogenesis and maintenance of the malignant phenotype of cancer and thereby many oncogenes and cell-signaling molecules present enticing drug target possibilities. RNAi, potent and specific, could silence tumor-related genes and would appear to be a rational approach to inhibit tumor growth. In subsequent in vivo studies, the appropriate cancer model must be developed for an evaluation of siRNA effects on tumors. How to evaluate the effect of siRNA in an in vivo therapeutic model is also important. Accelerating the analyses of these models and improving their predictive value through whole animal imaging methods, which provide cancer inhibition in real time and are sensitive to subtle changes, are crucial for rapid advancement of these approaches. Bioluminescent imaging is one of these optically based imaging methods that enable rapid in vivo analyses of a variety of cellular and molecular events with extreme sensitivity.
机译：RNAi已迅速成为体外培养系统中用于药物靶点发现和验证的强大工具，因此，对于将其应用扩展到体内系统（例如动物疾病模型和人类治疗剂）的兴趣迅速增长。癌症是RNAi治疗药物的一项显而易见的应用，因为据认为异常基因表达有助于癌症的恶性表型的发生和维持，因此许多致癌基因和细胞信号分子提供了诱人的药物靶标可能性。有力和特异性的RNAi可以沉默与肿瘤相关的基因，并且似乎是抑制肿瘤生长的合理方法。在随后的体内研究中，必须开发适当的癌症模型以评估siRNA对肿瘤的作用。如何评估siRNA在体内治疗模型中的作用也很重要。加快对这些模型的分析并通过整个动物成像方法提高其预测价值，这些方法可以实时抑制癌症并且对细微的变化敏感，对于这些方法的快速发展至关重要。生物发光成像是这些基于光学的成像方法之一，能够以极高的灵敏度对各种细胞和分子事件进行快速的体内分析。

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