Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants

机译：用可成像的表达GFP的鼠伤寒沙门氏菌营养缺陷型突变体对肿瘤的治疗靶向

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Tumor targeting Salmonella typhimurium has been developed. These bacteria were mutagenized and a strain auxotrophic for leucine and arguine was selected. This strain was also engineered to express GFP. This train, termed A1, could target prostate tumors in nude mouse models and inhibit their growth. A1 was passaged through a tumor and re-isolated and termed A1-R. A1-R had greater antitumor efficacy and could cure breast, prostate, pancreatic, and lung tumors in nude mouse models.

机译：已经开发了针对鼠伤寒沙门氏菌的肿瘤。诱变这些细菌，并选择了亮氨酸和精氨酸的营养缺陷型菌株。还对该菌株进行了工程改造以表达GFP。这列称为A1的火车可以靶向裸鼠模型中的前列腺肿瘤并抑制其生长。 A1穿过肿瘤并重新分离，称为A1-R。 A1-R具有更好的抗肿瘤功效，可以治愈裸鼠模型中的乳腺，前列腺，胰腺和肺部肿瘤。

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来源
《Conference on Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes; 20080121-22; San Jose,CA(US)》|2008年|P.ivii|共2页
会议地点 San JoseCA(US)
作者
Robert M. Hoffman; Katsuhiro Hayashi; Ming Zhao;
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作者单位

AntiCancer, Inc., 7917 Ostrow Street, San Diego, CA 92111-3604;

Dept. of Surgery, University of California, 200 W. Arbor Dr., San Diego, CA 92103-8220;

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会议组织
原文格式 PDF
正文语种 eng
中图分类医用物理学;
关键词
bacteria; auxotrophy; tumor targeting; GFP; imaging; tumor therapy;

机译：细菌;营养缺陷型;肿瘤靶向; GFP;显像;肿瘤治疗;

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专利

1. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium. [J] . Zhao M, Yang M, Li XM, Proceedings of the National Academy of Sciences of the United States of America . 2005,第3期

机译：表达GFP的鼠伤寒沙门氏菌的氨基酸营养缺陷型的靶向肿瘤细菌治疗。
2. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium Zhao M, Yang M, Li XM, Jiang P, Baranov E, Li S, Xu M, Penman S, Hoffman RM, AntiCancer, San Diego, CA. [J] . Trump DL Urologic oncology . 2005,第5期

机译：用表达GFP的鼠伤寒沙门氏菌的氨基酸营养缺陷型进行靶向肿瘤的细菌治疗赵M，杨M，李XM，姜P，巴拉诺夫E，李S，徐M，彭曼S，霍夫曼RM，抗癌，圣地亚哥，加利福尼亚。
3. Tumor-targeting amino acid auxotrophic Salmonella typhimurium [J] . Robert M. Hoffman Amino acids . 2009,第3期

机译：靶向肿瘤的氨基酸营养缺陷型鼠伤寒沙门氏菌
4. Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants [C] . Robert M. Hoffman, Katsuhiro Hayashi, Ming Zhao Conference on Small Animal Whole-Body Optical Imaging Based on Genetically Engineered Probes . 2008

机译：具有可成像GFP的肿瘤的治疗靶向肿瘤的沙门氏菌毒鼠卵硫醇植物突变体
5. Targeting bacteriolytic therapy of solid tumors with attenuated Salmonella typhimurium. [D] . Ganai, Sabha. 2007

机译：减毒鼠伤寒沙门氏菌对实体瘤的靶向溶菌治疗。
6. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium [O] . Ming Zhao, Meng Yang, Xiao-Ming Li, 2005

机译：表达GFP的鼠伤寒沙门氏菌的氨基酸营养缺陷型的靶向肿瘤细菌治疗
7. Tumor-targeting bacterial therapy with amino acid auxotrophs of GFP-expressing Salmonella typhimurium [O] . Zhao, Ming, Yang, Meng, Li, Xiao-Ming, 2005

机译：表达GFP的鼠伤寒沙门氏菌的氨基酸营养缺陷型的靶向肿瘤细菌治疗

Therapeutic targeting of tumors with imageable GFP-expressing Salmonella typhimurium auxotrophic mutants

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