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首页> 外文会议>Conference on Therapeutic Laser Applications and Laser-Tissue Interactions; Jun 24-25, 2003; Munich, Germany >Laser-induced micro-lesions as a tool for the anatomical-functional mapping of cerebral cortex
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Laser-induced micro-lesions as a tool for the anatomical-functional mapping of cerebral cortex

机译：激光诱导的微病变作为大脑皮质解剖功能定位的工具

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摘要

Small-size lesions to cerebral cortex induced by the CO_2 laser have found applications in neurophysiology for anatomical-functional mapping of the brain functions by areas. The advantage of this new technique in comparison to traditional ones (mechanical, electrical and chemical methods) consists in the possibility of making well-controlled lesions of small and repeatable size to cerebral cortex. In this work, we employed numerical and physical modelling to study the effect of the CO_2 laser beam diameter and power density on the ablation rate, size and shape of the laser-induced lesions. Our study showed that the existing linear mathematical model of the laser-induced ablation is sufficiently correct only for the case of relatively shallow lesions. For large penetration depths, the mathematical model of laser-tissue interaction that accounts for the exponential decay of laser power density with penetration depth gave better agreement with the experiment than the existing linear model.
机译：由CO_2激光引起的对大脑皮层的小损伤已在神经生理学中用于按区域划分大脑功能的解剖功能图。与传统方法（机械，电气和化学方法）相比，该新技术的优势在于可以对大脑皮层进行可控的小且可重复大小的病变。在这项工作中，我们采用数值和物理模型研究了CO_2激光束直径和功率密度对激光诱发病变的消融率，大小和形状的影响。我们的研究表明，仅在病变相对较浅的情况下，激光诱发的消融的线性数学模型才足够正确。对于较大的穿透深度，与现有的线性模型相比，解释激光功率密度随穿透深度呈指数下降的激光-组织相互作用的数学模型与实验具有更好的一致性。

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