• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Contemporary science of polymeric materials >Triphilic Block Copolymers: Synthesis, Aggregation Behavior and Interactions with Phospholipid Membranes
【24h】

Triphilic Block Copolymers: Synthesis, Aggregation Behavior and Interactions with Phospholipid Membranes

机译：三亲嵌段共聚物：合成，聚集行为和与磷脂膜的相互作用。

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Novel PPO-based amphiphilic diblock copolymer and triphilic multiblock copolymer analogues of the architectures BA, CBA, and CABAC have been successfully synthesized by combination of atom transfer radical polymerization (ATRP) and copper(I)-catalyzed alkyne-azide cycloaddition (CuAAC) 'click' post-polymerization reaction. The A, B, and C components of the block copolymers are formed by hydrophilic poly(glycerol monomethacrylate) (PGMA), lipophilic poly(propylene oxide) (PPO), and perfluoroalkyl segment, respectively. Their critical micelle concentrations in water are determined from surface tension measurements. Their aggregation behavior in aqueous medium is studied by temperature-dependent 'H- and I9F NMR spectroscopy. The presence of the perfluoro segments within the micelle cores of the triphilic block copolymers enhanced 3-4 folds their solubilization capacity of tetrafluorobenzene compared to micelle cores without the perfluoro segments. It is found that the triphilic copolymer inserts into lipid membranes and induces lateral demixing between the two homologue lipids in the temperature range of the phase transition of the lipids.
机译：通过原子转移自由基聚合（ATRP）和铜（I）催化的炔-叠氮化物环加成反应（CuAAC）的结合，成功合成了结构新颖的基于PPO的两亲性双嵌段共聚物和三亲性多嵌段共聚物类似物BA，CBA和CABAC。单击后聚合反应。嵌段共聚物的A，B和C组分分别由亲水性聚单甲基丙烯酸甘油酯（PGMA），亲脂性聚环氧丙烷（PPO）和全氟烷基链段形成。通过表面张力测量确定它们在水中的临界胶束浓度。它们在水性介质中的聚集行为通过与温度有关的1 H和19 F NMR光谱进行了研究。与没有全氟链段的胶束芯相比，三亲嵌段共聚物的胶束芯中的全氟链段的存在增强了其四氟苯的增溶能力的3-4倍。发现三亲共聚物插入脂质膜中并在脂质的相变温度范围内引起两个同系脂质之间的侧向混合。

著录项

  • 来源
  • 会议地点 Valletta(MT)
  • 作者

    S. O. Kyeremateng; C. Schwieger; A. Blume; J. Kressler;

  • 作者单位

    Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany;

    Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany;

    Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany;

    Department of Chemistry, Martin Luther University Halle-Wittenberg, D-06099 Halle (Saale), Germany;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TQ050.43;
  • 关键词

  • 入库时间 2022-08-26 14:19:56

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号