An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies

机译：临床研究中用于分析分子生物学数据的集成平台

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To investigate molecular-biological causes and effects of diseases and their therapies it becomes increasingly important to combine data from clinical trials with high volumes of experimental genetic data and annotations. We present our approach to integrate such data for two large collaborative cancer research studies in Germany. Our platform interconnects a commercial study management system (eRN) with a data warehouse-based gene expression analysis system (GeWare). We utilize a generic approach to import different anonymized pathological and patient-related annotations into the warehouse. The platform also integrates different forms of experimental data and public molecular-biological annotation data and thus supports a wide range of genetic analyses for both clinical and non-clinical parameters.

机译：为了研究疾病及其治疗的分子生物学原因和影响，将来自临床试验的数据与大量的实验遗传数据和注释相结合变得越来越重要。我们介绍了我们在德国进行的两项大型合作性癌症研究的综合数据的方法。我们的平台将商业研究管理系统（eRN）与基于数据仓库的基因表达分析系统（GeWare）互连在一起。我们利用通用方法将不同的匿名病理和与患者相关的注释导入仓库。该平台还整合了不同形式的实验数据和公共分子生物学注释数据，因此支持针对临床和非临床参数的广泛遗传分析。

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来源
《Current Trends in Database Technology - EDBT 2006; Lecture Notes in Computer Science; 4254》|2006年|399-410|共12页
会议地点 Munich(DE);Munich(DE)
作者
Toralf Kirsten; Joerg Lange; Erhard Rahm;
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作者单位

Interdisciplinary Center for Bioinformatics Leipzig, University of Leipzig;

Dept. of Computer Science, University of Leipzig;

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原文格式 PDF
正文语种 eng
中图分类 TP311.13;
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专利

1. The GeWare data warehouse platform for the analysisof molecular-biological and clinical data [J] . Erhard Rahm, Toralf Kirsten, J?rg Lange Journal of Integrative Bioinformatics . 2007,第1期

机译：GeWare数据仓库平台，用于分析分子生物学和临床数据
2. RD-Connect: Data sharing and analysis for rare disease research within the integrated platform and through GA4GH beacon and matchmaker exchange [J] . Roos A., Beltran S., Piscia D., Neuromuscular disorders: NMD . 2016,第Suppla2期

机译：RD-Connect：在集成平台内以及通过GA4GH信标和媒人交换来进行罕见病研究的数据共享和分析
3. An integrated analysis platform merging SuperDARN data within the THEMIS tool developed by ERG-Science Center (ERG-SC) [J] . Tomoaki Hori, Nozomu Nishitani, Yoshizumi Miyoshi, 极地科学进展(英文版) . 2013,第001期

机译：一个集成的分析平台，将由ERG-科学中心（ERG-SC）开发的THEMIS工具中的SuperDARN数据合并
4. A New Integrated Platform for Gathering and Managing Multivariable and Multisensor Data in Diabetes Clinical Studies [C] . Cossu Luca, Cappon Giacomo, Sparacino Giovanni, E-Health and Bioengineering Conference . 2020

机译：一种新的集成平台，用于在糖尿病临床研究中收集和管理多变量和多传感器数据
5. Statistical Methods for Analyzing DNA Methylation Data and Subpopulation Analysis of Continuous, Binary and Count Data for Clinical Trials [D] . Yip, Wai-Ki 2015

机译：用于临床试验的DNA甲基化数据分析和连续，二进制和计数数据亚群分析的统计方法
6. Integrated study of 100 patients with Xp21 linked muscular dystrophy using clinical genetic immunochemical and histopathological data. Part 2. Correlations within individual patients. [O] . L V Nicholson, M A Johnson, K M Bushby, 1993

机译：使用临床遗传免疫化学和组织病理学数据对100例Xp21连锁肌营养不良患者进行综合研究。第2部分。个别患者之间的相关性。
7. The GeWare data warehouse platform for the analysis of molecular-biological and clinical data [O] . Rahm Erhard, Kirsten Toralf, Lange Jörg 2007

机译：GeWare数据仓库平台，用于分析分子生物学和临床数据
8. Study Program for Analyzing Data Handling Capability of a 240Hz. Slot within a Normal Voice Band. [R] . affeldt, f. moors, r. 1978

机译：分析240Hz数据处理能力的研究程序。普通语音频段内的插槽。

An Integrated Platform for Analyzing Molecular-Biological Data Within Clinical Studies

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