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首页> 外文会议>Design and performance validation of phantoms used in conjunction with optical measurement of tissue V >Development of a QDots 800 based fluorescent solid phantom for validation of NIRF imaging platforms
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Development of a QDots 800 based fluorescent solid phantom for validation of NIRF imaging platforms

机译：基于QDots 800的荧光固体模型的开发，用于验证NIRF成像平台

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Over the past decade, we developed near-infrared fluorescence (NIRF) devices for non-invasive lymphatic imaging using microdosages of ICG in humans and for detection of lymph node metastasis in animal models mimicking metastatic human prostate cancer. To validate imaging, a NIST traceable phantom is needed so that developed "first-in-humans" drugs may be used with different fluorescent imaging platforms. In this work, we developed a QDots 800 based fluorescent solid phantom for installation and operational qualification of clinical and preclinical, NIRF imaging devices. Due to its optical clearance, polyurethane was chosen as the base material. Titanium dioxide was used as the scattering agent because of its miscibility in polyurethane. QDots 800 was chosen owing to its stability and NIR emission spectra. A first phantom was constructed for evaluation of the noise floor arising from excitation light leakage, a phenomenon that can be minimized during engineering and design of fluorescent imaging systems. A second set of phantoms were constructed to enable quantification of device sensitivity associated with our preclinical and clinical devices. The phantoms have been successfully applied for installation and operational qualification of our preclinical and clinical devices. Assessment of excitation light leakage provides a figure of merit for "noise floor" and imaging sensitivity can be used to benchmark devices for specific imaging agents.
机译：在过去的十年中，我们开发了近红外荧光（NIRF）装置，用于使用人类ICG的微剂量进行非侵入性淋巴成像，以及在模拟转移性人类前列腺癌的动物模型中检测淋巴结转移。为了验证成像，需要NIST可追踪的体模，以便开发的“人类首创”药物可与不同的荧光成像平台一起使用。在这项工作中，我们开发了基于QDots 800的荧光固体体模，用于临床和临床前NIRF成像设备的安装和操作鉴定。由于其光学间隙，聚氨酯被选为基础材料。由于二氧化钛可与聚氨酯混溶，因此将其用作散射剂。选择QDots 800是因为它具有稳定性和NIR发射光谱。构造了第一个模型以评估由激发光泄漏引起的本底噪声，这种现象可以在荧光成像系统的工程设计中最小化。构造了第二组模型，以量化与我们的临床前和临床设备相关的设备灵敏度。幻影已成功应用于我们的临床前和临床设备的安装和操作鉴定。激发光泄漏的评估提供了“噪底”的品质因数，并且成像灵敏度可用于对特定成像剂进行基准测试。

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