首页> 外文会议>Design and quality for biomedical technologies X >Near-infrared fluorescence image quality test methods for standardized performance evaluation
【24h】

Near-infrared fluorescence image quality test methods for standardized performance evaluation

机译:用于标准性能评估的近红外荧光图像质量测试方法

获取原文
获取原文并翻译 | 示例

摘要

Near-infrared fluorescence (NIRF) imaging has gained much attention as a clinical method for enhancing visualization of cancers, perfusion and biological structures in surgical applications where a fluorescent dye is monitored by an imaging system. In order to address the emerging need for standardization of this innovative technology, it is necessary to develop and validate test methods suitable for objective, quantitative assessment of device performance. Towards this goal, we develop target-based test methods and investigate best practices for key NIRF imaging system performance characteristics including spatial resolution, depth of field and sensitivity. Characterization of fluorescence properties was performed by generating excitation-emission matrix properties of indocyanine green and quantum dots in biological solutions and matrix materials. A turbid, fluorophore-doped target was used, along with a resolution target for assessing image sharpness. Multi-well plates filled with either liquid or solid targets were generated to explore best practices for evaluating detection sensitivity. Overall, our results demonstrate the utility of objective, quantitative, target-based testing approaches as well as the need to consider a wide range of factors in establishing standardized approaches for NIRF imaging system performance.
机译:近红外荧光(NIRF)成像作为一种临床方法得到了广泛的关注,该方法用于增强外科手术应用中的癌症,灌注和生物结构的可视化,在该应用中,通过成像系统监控荧光染料。为了满足这种创新技术标准化的新兴需求,有必要开发和验证适合客观,定量评估设备性能的测试方法。为了实现这一目标,我们开发了基于目标的测试方法,并研究了关键NIRF成像系统性能特征(包括空间分辨率,景深和灵敏度)的最佳做法。荧光特性的表征是通过在生物溶液和基质材料中生成吲哚菁绿和量子点的激发-发射基质特性来进行的。使用了浑浊的,掺有荧光团的靶以及用于评估图像清晰度的分辨率靶。生成填充有液体或固体靶标的多孔板,以探索评估检测灵敏度的最佳方法。总体而言,我们的结果证明了客观,定量,基于目标的测试方法的实用性,以及在建立NIRF成像系统性能的标准化方法时需要考虑多种因素。

著录项

  • 来源
    《Design and quality for biomedical technologies X》|2017年|100560J.1-100560J.8|共8页
  • 会议地点 San Francisco(US)
  • 作者单位

    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 USA,Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA;

    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 USA;

    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 USA;

    Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA;

    Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA;

    Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742 USA;

    Center for Devices and Radiological Health, U.S. Food and Drug Administration, Silver Spring, MD 20993 USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Keywords:; Epoxy resin phantom; Polyurethane phantom; Quantum dot; Indocyanine Green; Image quality characteristics;

    机译:关键词:环氧树脂幻影;聚氨酯幻影;量子点吲哚菁绿;图像质量特征;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号