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Development of lung tissue phantoms for bioluminescent imaging

机译：用于生物发光成像的肺部组织体模的开发

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White nylon material was chosen to make cylindrical tissue phantoms for development of bioluminescence tomography techniques. A low-level light source, delivered through a optic fiber of core diameter 200 μm. was placed at different locations on one phantom surface. The light travels through the phantom, reaches the external surface, and is captured by a liquid nitrogen-cooled CCD camera. The scattering, absorption, and anisotropy parameters of the phantom are obtained by matching the measured light transmission profiles to the profiles generated by the TracePro software. The perturbation analysis, with the homogeneous phantoms, demonstrated that the imaging system is sufficiently sensitive to capture intensity change of higher than 0.5nW/cm~2 or a location shift of the light source of more than 200microns. It is observed that the system can distinguish two point light sources with separation of about 2mm. The perturbation analysis is also performed with the heterogeneous phantom. Based on our data, we conclude that there is inherent tomographic information in bioluminescent measures taken on the external surface of the mouse, which suggests the feasibility of bioluminescence tomography for biomedical research using the small animals, especially the mice.
机译：选择白色尼龙材料制成圆柱形组织体模，以开发生物发光层析成像技术。通过核心直径为200μm的光纤传输的低级光源。被放置在一个幻影表面上的不同位置。光穿过人体模型，到达外表面，并被液氮冷却的CCD相机捕获。体模的散射，吸收和各向异性参数是通过将测得的光透射轮廓与TracePro软件生成的轮廓进行匹配而获得的。用均质体模进行的扰动分析表明，成像系统足够灵敏，可以捕获大于0.5nW / cm〜2的强度变化或大于200微米的光源位置偏移。可以观察到，该系统可以区分大约2mm的两个点光源。扰动分析也使用异质模型进行。根据我们的数据，我们得出结论，在小鼠外表面采取的生物发光措施中存在固有的层析成像信息，这表明使用生物发光层析成像技术对使用小型动物（尤其是小鼠）进行生物医学研究的可行性。

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