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首页> 外文会议>Developments in X-ray tomography XI >Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography
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Biodegradable magnesium-based implants in bone studied by synchrotron radiation microtomography

机译：同步辐射显微断层照相术研究可生物降解的镁基骨植入物

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摘要

Permanent implants made of titanium or its alloys are the gold standard in many orthopedic and traumatological applications due to their good biocompatibility and mechanical properties. However, a second surgical intervention is required for this kind of implants as they have to be removed in the case of children that are still growing or on patient's demand. Therefore, magnesium-based implants are considered for medical applications as they are degraded under physiological conditions. The major challenge is tailoring the degradation in a manner that is suitable for a biological environment and such that stabilization of the bone is provided for a controlled period. In order to understand failure mechanisms of magnesium-based implants in orthopedic applications and, further, to better understand the osseointegration, screw implants in bone are studied under mechanical load by means of a push-out device installed at the imaging beamline P05 of PETRA Ⅲ at DESY. Conventional absorption contrast microtomography and phase-contrast techniques are applied in order to monitor the bone-to-implant interface under increasing load conditions. In this proof-of-concept study, first results from an in situ push-out experiment are presented.
机译：由于钛具有良好的生物相容性和机械性能，因此由钛或其合金制成的永久性植入物在许多骨科和创伤学应用中都是金标准。但是，这种植入物需要第二次外科手术，因为对于仍在成长中的儿童或应患者需求，必须将其移除。因此，由于镁基植入物在生理条件下会降解，因此被认为可用于医学领域。主要挑战是以适合于生物环境的方式定制降解，并在受控的时间内提供骨骼的稳定性。为了了解整形外科应用中镁基植入物的失效机理，并且为了更好地了解骨整合，我们通过安装在PETRAⅢ成像束线P05上的推出装置，在机械负载下研究了骨螺钉植入物在机械负载下的情况。在DESY。为了在增加的载荷条件下监测骨与植入物的界面，应用了常规的吸收对比显微照相术和相衬技术。在此概念验证研究中，提出了原位推出实验的第一个结果。

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  • 来源
    《Developments in X-ray tomography XI》|2017年|103910O.1-103910O.9|共9页
  • 会议地点 San Diego(US)
  • 作者

    Julian Moosmann; Berit Zeller-Plumhoff; D. C. Florian Wieland; Silvia Galli; Diana Krueger; Thomas Dose; Hilmar Burmester; Fabian Wilde; Martin Bech; Niccolo Peruzzi; Bjoern Wiese; Alexander Hipp; Felix Beckmann; Joerg Hammel; Regine Willumeit-Roemer;

  • 作者单位

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Facuity of Odontology, Malmoe University, 205 06 Malmoe, Sweden;

    Clinical Sciences, Lund University, 221 85 Lund, Sweden;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Clinical Sciences, Lund University, 221 85 Lund, Sweden;

    Clinical Sciences, Lund University, 221 85 Lund, Sweden;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany;

    Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, D-21502 Geesthacht, Germany,Institute of Materials Science, Christian-Albrechts-Universitaet zu Kiel, Christian- Albrechts-Platz 4, D-24118 Kiel, Germany;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Magnesium alloys; biodegradation; biodegradable metallic implants; bone-implant-interface; bone healing; X-ray tomography; synchrotron radiation; microCT; in situ mechanical testing; load frame;

    机译：镁合金；生物降解可生物降解的金属植入物；骨-植入物界面骨骼愈合； X射线断层扫描；同步辐射microCT;原位机械测试；负荷框架;

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