Nanoscale holographic tomography of heart tissue with x-ray waveguide optics

机译：使用X射线波导光学器件对心脏组织进行纳米级全息层析成像

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In this work we present x-ray phase-contrast tomography of heart tissue from mouse, combining computed tomography (CT) scans with laboratory and synchrotron radiation. The work serves as a proof-of-concept that the cyto-architecture and in particular the myofibril orientation can be assessed in three dimensions (3D) by phase-contrast CT. We demonstrate the synergistic use of laboratory μ-CT and of the high resolution synchrotron setup based on waveguide optics. Details on preparation, instrumentation and analysis are given, as a state of the art reference for heart tissue tomography, and as a starting point for further progress.

机译：在这项工作中，我们将结合计算机断层扫描（CT）扫描与实验室和同步加速器辐射，对小鼠心脏组织进行X射线相衬层析。这项工作是一种概念证明，可以通过相衬CT在三个维度（3D）上评估细胞结构，尤其是肌原纤维的取向。我们演示了实验室μ-CT和基于波导光学器件的高分辨率同步加速器装置的协同使用。给出了有关准备，仪器和分析的详细信息，作为心脏组织断层扫描的最新技术参考，并作为进一步发展的起点。

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来源
《Developments in X-ray tomography XI》|2017年|1039105.1-1039105.12|共12页
会议地点 San Diego(US)
作者
M. Reichardt; J. Frohn; M. Toepperwien; J.-D. Nicolas; A. Markus; F. Alves; T. Salditt;
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作者单位

Institute for X-Ray Physics, Georg-August-University Goettingen, Friedrich-Hund-Platz 1, Gottingen 37077, Germany;

Institute for X-Ray Physics, Georg-August-University Goettingen, Friedrich-Hund-Platz 1, Gottingen 37077, Germany;

Institute for X-Ray Physics, Georg-August-University Goettingen, Friedrich-Hund-Platz 1, Gottingen 37077, Germany;

Institute for X-Ray Physics, Georg-August-University Goettingen, Friedrich-Hund-Platz 1, Gottingen 37077, Germany;

Max Planck Institute for Experimental Medicine, Herman-Rein-Str. 3, Goettingen 37077,Germany;

Max Planck Institute for Experimental Medicine, Herman-Rein-Str. 3, Goettingen 37077,Germany,Clinic of Haematology and Medical Oncology, University Medical Center Gottingen, Robert Koch Strasse 40, Gottingen 37075, Germany;

Institute for X-Ray Physics, Georg-August-University Goettingen, Friedrich-Hund-Platz 1, Gottingen 37077, Germany;

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正文语种 eng
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关键词
X-ray tomography; phase contrast; in-line holography; 3D virtual histology; heart tissue;

机译：X射线断层扫描；相衬在线全息术； 3D虚拟组织学；心脏组织;

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4. Nanoscale holographic tomography of heart tissue with x-ray waveguide optics [C] . M. Reichardt, J. Frohn, M. Toepperwien, Conference on developments in X-ray tomography XI . 2017

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5. Novel nonlinear optics and quantum optics approaches for ultrasound-modulated optical tomography in soft biological tissue [D] . Zhang, Huiliang 2010

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7. Nanoscale holographic tomography of heart tissue with x-ray waveguide optics [O] . Tim Salditt, Mareike Toepperwien, Marius Reichardt, 2017

机译：纳米级全息层析术与X射线波导光学

Nanoscale holographic tomography of heart tissue with x-ray waveguide optics

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