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Semi-analytical method for rapid calculation of time-resolved reflectance from bi-layered tissue models

机译:从双层组织模型快速计算时间分辨反射率的半分析方法

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摘要

Photon transport in complex biological tissues is most accurately predicted via Monte Carlo (MC) modeling methods, which often require lengthy computation times. In this report, a semi-analytical technique (henceforth referred to as PI-scaling) was derived that combines MC simulation, absorption scaling, and path integrals (PI) to rapidly reconstruct time-resolved reflectance from the surface of bi-layered epithelial tissue models. Comparisons to forward MC simulations indicated that the PI-scaling method was accurate to better than 10% for tissue models where the optical properties of the top layer did not greatly influence the time-resolved reflectance. Employing such a method should provide a novel solution to the first step of the problem of rapid simulation of time-resolved reflectance of photons in layered tissues.
机译:通过蒙特卡洛(MC)建模方法可以最准确地预测复杂生物组织中的光子传输,这通常需要漫长的计算时间。在本报告中,获得了一种半分析技术(以下称为PI缩放),该技术结合了MC模拟,吸收缩放和路径积分(PI),可以从双层上皮组织表面快速重建时间分辨的反射率楷模。与正向MC模拟的比较表明,对于组织模型,PI缩放方法的准确性优于10%,在组织模型中,顶层的光学特性不会极大地影响时间分辨的反射率。采用这种方法应该为快速模拟分层组织中光子的时间分辨反射率问题的第一步提供新颖的解决方案。

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