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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Computational circular dichroism estimation for point-of-care diagnostics via vortex half-wave retarders
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Computational circular dichroism estimation for point-of-care diagnostics via vortex half-wave retarders

机译：通过涡旋半波延迟器进行现场诊断的计算圆二色性估计

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Observing the circular dichroism (CD) caused by organic molecules in biological fluids can provide powerful indicators of patient health and provide diagnostic clues for treatment. Methods for this kind of analysis involve tabletop devices that weigh tens of kilograms with costs on the order of tens of thousands of dollars, making them prohibitive in point-of-care diagnostic applications. In an effort to reduce the size, cost, and complexity of CD estimation systems for point-of-care diagnostics, we propose a novel method for CD estimation that leverages a vortex half-wave retarder in between two linear polarizers and a two-dimensional photodetector array to provide an overall complexity reduction in the system. This enables the measurement of polarization variations across multiple polarizations after they interact with a biological sample, simultaneously, without the need for mechanical actuation. We further discuss design considerations of this methodology in the context of practical applications to point-of-care diagnostics.
机译：观察由生物液体中的有机分子引起的圆二色性（CD）可以为患者的健康状况提供有力的指标，并为治疗提供诊断线索。这种分析方法涉及重达数十公斤的台式设备，成本约为数万美元，这使得它们在即时医疗诊断应用中望而却步。为了减少用于即时诊断的CD估计系统的尺寸，成本和复杂性，我们提出了一种CD估计的新方法，该方法在两个线性偏振器和一个二维偏振器之间利用涡旋半波延迟器光电探测器阵列可降低系统的总体复杂度。这样，就可以测量多个极化同时与生物样品相互作用后跨多个极化的极化变化，而无需进行机械驱动。我们将在现场诊断的实际应用中进一步讨论此方法的设计注意事项。

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