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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >In vivo near infrared (NIRS) sensor attachment using fibrin bioadhesive
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In vivo near infrared (NIRS) sensor attachment using fibrin bioadhesive

机译：使用纤维蛋白生物粘附剂的体内近红外（NIRS）传感器附件

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摘要

Background: 'Tisseel' (Baxter Healthcare, Deerfield, IL) is a fibrin-based sealant that is commonly used during spine surgery to augment dural repairs. We wish to intra-operatively secure a near infrared spectroscopy (NIRS) sensor to the dura in order to monitor the tissue hemodynamics of the underlying spinal cord. To determine if 'Tisseel' sealant adversely attenuates NIR photon transmission. Methods: We investigated 'Tisseel' in both an in vitro and in vivo paradigm. For in vitro testing, we used a 1 mm pathlength cuvette containing either air or 'Tisseel' interposed between a NIR light source (760 and 850 nm) and a photodiode detector and compared transmittance. For in vivo testing, a continuous wave (760 and 850 nm) spatially-resolved NIRS device was placed over the triceps muscle using either conventional skin apposition (overlying adhesive bandage) or bioadhesion with 'Tisseel'. Raw optical data and tissue saturation index (TSI%) collected at rest were compared. Results: In-vitro NIR light absorption by 'Tisseel' was very high, with transmittance reduced by 95% compared to air. In-vivo muscle TSI% values were 80% with conventional attachment and 20% using fibrin glue. Conclusion: The optical properties of 'Tisseel' significantly attenuate NIR light during in-vitro transmittance and critically compromise photon transmission in-vivo.
机译：背景：“ Tisseel”（Baxter Healthcare，Deerfield，伊利诺伊州）是一种基于纤维蛋白的密封剂，通常在脊柱外科手术期间用于增强硬膜修复。我们希望在手术中将近红外光谱（NIRS）传感器固定在硬脑膜上，以监测下方脊髓的组织血流动力学。确定“ Tisseel”密封胶是否会对NIR光子传输产生不利影响。方法：我们在体外和体内范例中研究了“ Tisseel”。对于体外测试，我们使用了1mm光程比色皿，其中包含空气或“ Tisseel”，置于NIR光源（760和850 nm）与光电二极管检测器之间，并比较了透射率。为了进行体内测试，使用常规的皮肤贴合（覆盖创可贴）或用“ Tisseel”进行生物粘合将连续波（760和850 nm）的空间分辨NIRS装置放置在肱三头肌上。比较原始光学数据和静止时收集的组织饱和指数（TSI％）。结果：“ Tisseel”在体外的NIR光吸收非常高，与空气相比，透射率降低了95％。使用常规附件时，体内肌肉TSI％值为80％，使用纤维蛋白胶时为20％。结论：“ Tisseel”的光学特性在体外透射过程中会显着衰减NIR光，并严重损害体内的光子透射。

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  • 会议地点 San Francisco(US)
  • 作者

    Andrew Macnab; Roberto Pagano; Brian Kwon; Guy Dumont; Babak Shadgan;

  • 作者单位

    Stellenbosch Inst. for Advanced Study, Wallenberg Research Centre, Stellenbosch, South Africa;

    Electrical Computer Engineering in Medicine, Pediatric Anesthesia Research Team, University of British Columbia, Vancouver, Canada;

    International Collaboration on Repair Discoveries (ICORD), Vancouver, Canada,Department of Orthopaedics, University of British Columbia, Vancouver, Canada;

    Electrical Computer Engineering in Medicine, Pediatric Anesthesia Research Team, University of British Columbia, Vancouver, Canada;

    International Collaboration on Repair Discoveries (ICORD), Vancouver, Canada,Department of Orthopaedics, University of British Columbia, Vancouver, Canada;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    fibrin sealant; fibrin glue; near infrared spectroscopy; NIRS; sensor fixation;

    机译：纤维蛋白密封胶纤维蛋白胶近红外光谱NIRS；传感器固定;

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