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首页> 外文会议>Optical diagnostics and sensing XVIII: Toward Point-of-Care Diagnostics >Toward noninvasive detection and monitoring of malaria with broadband diffuse optical spectroscopy
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Toward noninvasive detection and monitoring of malaria with broadband diffuse optical spectroscopy

机译：借助宽带漫射光谱技术实现对疟疾的无创检测和监测

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摘要

Despite numerous advances, malaria continues to kill nearly half a million people globally every year. New analytical methods and diagnostics are critical to understanding how treatments under development affect the lifecycle of malaria parasites. A biomarker that has been gaining interest is the"malaria pigment" hemozoin. This byproduct of hemoglobin digestion by the parasite has a unique spectral signature but is difficult to differentiate from hemoglobin and other tissue chromophores. Hemozoin can be detected in blood samples, but only utilizing approaches that require specialized training and facilities. Diffuse optical spectroscopy (DOS) is a noninvasive sensing technique that is sensitive to near-infrared absorption and scattering and capable of probing centimeter-deep volumes of tissue in vivo. DOS is relatively low-cost, does not require specialized training and thus potentially suitable for use in low-resource settings. In this work, we assess the potential of DOS to detect and quantify the presence of hemozoin noninvasively and at physiologically relevant levels. We suspended synthetic hemozoin in Intralipid-based tissue-simulating phantoms in order to mimic malaria infection in multiply-scattering tissue. Using a fiber probe that combines frequency-domain and continuous-wave broadband DOS (650-1000 nm). we detected hemozoin concentrations below 250 ng/ml. which corresponds to parasitemia sensitivities comparable to modern rapid diagnostic tests. We used the experimental variability to simulate and estimate the sensitivity of DOS to hemozoin in tissue that includes hemoglobin, water, and lipid under various tissue oxygen saturation levels. The results indicate that with increased precision, it may be possible to detect Hz noninvasively with DOS.
机译：尽管取得了许多进步，但疟疾每年仍在全球造成近50万人死亡。新的分析方法和诊断方法对于了解正在开发的疗法如何影响疟原虫生命周期至关重要。一种已经引起人们兴趣的生物标记物是“疟疾色素”血红蛋白。这种被寄生虫消化的血红蛋白副产物具有独特的光谱特征，但很难与血红蛋白和其他组织发色团区分开。可以在血液样本中检测到血红蛋白，但只能采用需要专门培训和设施的方法。漫射光谱法（DOS）是一种非侵入性传感技术，对近红外吸收和散射敏感，并且能够探测体内厘米级深的组织。 DOS的成本相对较低，不需要专门的培训，因此可能适合在资源匮乏的环境中使用。在这项工作中，我们评估了DOS在非侵入性和生理学相关水平上检测和定量hemozoin的潜力。为了模拟多重散射组织中的疟疾感染，我们将合成的hezozoin悬浮在基于脂质的组织模拟模型中。使用结合了频域和连续波宽带DOS（650-1000 nm）的光纤探头。我们检测到的血红蛋白浓度低于250 ng / ml。与现代快速诊断测试相当的寄生虫血症敏感性。我们使用实验变异性来模拟和估计DOS对组织中血红蛋白的敏感性，包括在各种组织氧饱和度水平下的血红蛋白，水和脂质。结果表明，以更高的精度，可以用DOS无创地检测Hz。

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