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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Wavelengths optimization in multi spectral diffuse optical tomography considering uncertainties in absorption spectra
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Wavelengths optimization in multi spectral diffuse optical tomography considering uncertainties in absorption spectra

机译：考虑吸收光谱不确定性的多光谱漫射光学层析成像中的波长优化

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Using multiple lasers in continuous wave diffuse optical tomography has the advantages that scattering and absorption can be distinguished, and that physiological parameters (chromophore concentrations) can be reconstructed. The choice of the laser wavelengths is crucial to ensure a good separability of scattering and chromophores. Current methods to optimize the wavelengths do not consider the sensitivity of the reconstruction result to deviations of extinction coefficients of the chromophores. But since the available absorption spectra for the individual chromophores show significant deviations, it seems to be necessary to take this into account when optimizing the wavelengths. The wavelength optimization approach presented here is an extension of a method of Corlu et al. An additional criterion is introduced, which evaluates the dependence of reconstructed chromophore concentrations on deviations of the absorption coefficients. The wavelengths found by the new approach are compared to those resulting from the original method. Reconstructions of simulated data show the effect of using various spectra for reconstruction with different wavelength sets and illustrate the advantages of the new wavelength sets, leading to less crosstalk between the chromophore concentrations and lower artifacts.
机译：在连续波漫射光学层析成像中使用多个激光器的优点是，可以区分散射和吸收，并且可以重建生理参数（生色团浓度）。激光波长的选择对于确保散射和生色团的良好分离性至关重要。当前优化波长的方法没有考虑重建结果对生色团消光系数偏差的敏感性。但是，由于各个发色团的可用吸收光谱显示出明显的偏差，因此在优化波长时似乎有必要将其考虑在内。这里介绍的波长优化方法是Corlu等人方法的扩展。引入了另一个标准，该标准评估了重建的生色团浓度对吸收系数偏差的依赖性。将新方法发现的波长与原始方法得到的波长进行比较。对模拟数据的重建显示了使用各种光谱对不同波长组进行重建的效果，并说明了新波长组的优势，从而减少了生色团浓度之间的串扰，并降低了伪影。

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