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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Time-of-flight non-contact fluorescence diffuse optical tomography with numerical constant fraction discrimination
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Time-of-flight non-contact fluorescence diffuse optical tomography with numerical constant fraction discrimination

机译：飞行时间非接触式荧光漫射光学层析成像，具有数值常数分数判别

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摘要

We introduce a novel non-contact fluorescence diffuse optical tomography (FDOT) approach for localizing a fluorescent inclusion embedded in a scattering medium. It uses the time of flight of early photons arriving at several detector positions around the medium. It is a true and direct time-of-flight approach in that arrival times are converted to distance. The arrival time of early photons is found via a recently introduced numerical constant fraction discriminator applied to fluoresced photons time-of-flight distributions (fluorescence time point-spread functions (FTPSFs)). Time-correlated single photon counting and an ultrafast photon counting avalanche photodiode are used for measuring FTPSFs that form tomographic data sets. The FDOT localization algorithm proceeds in two steps. The first determines the angular position of the inclusion as the average, over projections, of angular detector positions with smallest arrival time. The second determines the inclusion's radial position based on relative arrival times obtained at several detector positions within each tomographic projection relatively to a reference detector position, the latter being that of shortest arrival time in the projection. The radial position found minimizes the discrepancy between relative arrival times computed for several possible inclusion positions and relative arrival times deduced from experimental data. Two methods are presented for this.
机译：我们介绍了一种新颖的非接触式荧光漫射光学层析成像（FDOT）方法，用于定位嵌入在散射介质中的荧光包裹体。它使用早期光子到达介质周围多个检测器位置的飞行时间。这是一种真实而直接的飞行时间方法，即将到达时间转换为距离。早期光子的到达时间可通过最近引入的应用于荧光光子飞行时间分布的数值常数分数鉴别器（荧光时间点扩展函数（FTPSF））找到。时间相关的单光子计数和超快光子计数雪崩光电二极管用于测量形成层析数据集的FTPSF。 FDOT本地化算法分两个步骤进行。第一个将夹杂物的角位置确定为到达时间最短的角度检测器位置的平均投影值。第二种方法基于相对于参考检测器位置的每个断层摄影投影中几个检测器位置获得的相对到达时间，确定相对于参考检测器位置的夹杂物的径向位置，后者是投影中最短的到达时间。所找到的径向位置将为几个可能的夹杂位置计算的相对到达时间与从实验数据推导出的相对到达时间之间的差异最小化。为此提供了两种方法。

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