• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Radiotherapy dosimetry assessment with Optical Projection Tomography
【24h】

Radiotherapy dosimetry assessment with Optical Projection Tomography

机译：光学投影断层摄影术进行放射治疗剂量学评估

获取原文
获取原文并翻译 | 示例
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recent advances in radiotherapy have created the need to develop novel methods for the accurate, three-dimensional assessment of the applied radiation dose during specific radiotherapy plans. Here we present a study based on the use of polymer gel dosimeters in combination with a novel Optical Projection Tomography system, which allows the association of optical properties, namely the attenuation coefficient, to the irradiation dose. Polymer gel dosimeters are polymerized after X-ray irradiation via free radical production during water radiolysis resulting to increased optical opacity as well as change of the nuclear magnetic resonance relaxation times, thus making it possible to study them with both optical and MRI techniques. The optical tomographic system employs a sensitive CCD camera, a rotation stage allowing full 360 degrees rotation and a homogeneous white light source transilluminating the samples. This setup allows the calculation of the optical attenuation coefficient which can then be directly related to the applied radiotherapy dose, as well as the definition of the surface of the sample in space. The experimental procedure involves the recording of transillumination images of the polymer samples in steps of 1 degree to get the desired resolution. Data analysis is performed by back propagating the photons using an inverse Radon transform resulting to the reconstruction of three dimensional images of the attenuation coefficient or equivalently the dose distribution. The sensitivity and dynamic range offered by the technique covers the range of radiotherapy doses in modern clinical practice and are compared with the corresponding achieved with MRI.
机译：放射疗法的最新进展引起了对开发新方法的需求，该方法用于在特定放射疗法计划期间对施加的放射剂量进行准确的三维评估。在这里，我们基于聚合物凝胶剂量计与新型光学投影层析成像系统的结合进行了一项研究，该系统允许将光学特性（即衰减系数）与辐照剂量相关联。 X射线辐照后，聚合物凝胶剂量计在水分解过程中会通过自由基生成而聚合，从而导致不透明性增加以及核磁共振弛豫时间发生变化，因此可以同时使用光学和MRI技术进行研究。光学层析成像系统采用了一个灵敏的CCD相机，一个可进行360度全方位旋转的旋转台​​以及一个均匀透射样品的均匀白光源。这种设置允许计算光衰减系数，然后可以将其直接与所应用的放射治疗剂量以及空间中样品表面的定义相关。实验过程包括以1度的步长记录聚合物样品的透射照光图像，以获得所需的分辨率。通过使用反向Radon变换反向传播光子来执行数据分析，从而重建衰减系数或等效剂量分布的三维图像。该技术提供的灵敏度和动态范围涵盖了现代临床实践中的放射治疗剂量范围，并与MRI所达到的相对应性进行了比较。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号