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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Development of a computer vision binocular system for non-contact small animal model skin cancer tumour imaging
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Development of a computer vision binocular system for non-contact small animal model skin cancer tumour imaging

机译：用于非接触式小动物模型皮肤癌肿瘤成像的计算机视觉双目系统的开发

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摘要

This paper describes the development of a novel gauging computer vision system for murine non-melanoma skin cancer tumours volume imaging. The system utilized binocular stereovision, enhanced through the use of telecentric lenses. These lenses optically compromised for the distortion factors and provided orthographic projection, leading to parallax free image acquisition. In order to improve the resolution of the system, a structured light projector, with 450 nm dominant wavelength, was used to illuminate the target with a custom pattern. Robust image processing algorithms granted accurate segmentation, feature recognition, labeling and correlation between the stereo pairs. Under these premises, the well-known "matching" problem was resolved successfully and geometrical interpolation provided an accurate three-dimensional reconstruction of the tumour volume. Through back-projection of the calibration object the resolution of the system was calculated up to 0.04 mm. The system was applied to measure the induced geometrical alterations of the tumour after PDT by using the Fosgel photosensitizer, excited by a laser diode emitting at 652 nm. The measurement of the volume induced alterations after each PDT treatment and up to the final tumour shrinkage is critical, to compare PDT efficacy between different protocols.
机译：本文介绍了一种用于小鼠非黑素瘤皮肤癌肿瘤体积成像的新型计量计算机视觉系统的开发。该系统利用双目立体视觉，并通过使用远心镜头来增强。这些镜头在光学上受到畸变因素的影响，并提供正交投影，从而实现了无视差的图像采集。为了提高系统的分辨率，使用了具有450 nm主波长的结构化投光器以自定义图案照射目标。强大的图像处理算法可实现立体对之间的精确分割，特征识别，标记和相关。在这些前提下，成功解决了众所周知的“匹配”问题，并且几何插值提供了肿瘤体积的精确三维重建。通过对校准对象进行反投影，可以计算出系统的分辨率，最高可达0.04 mm。通过使用由在652 nm处发射的激光二极管激发的Fosgel光敏剂，将该系统应用于测量PDT后肿瘤的诱导几何变化。每次PDT治疗后直至最终肿瘤缩小的体积诱发变化的测量至关重要，以比较不同方案之间的PDT功效。

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