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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Imaging of Hemodynamic Effects in Arthritic Joints with Dynamic Optical Tomography
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Imaging of Hemodynamic Effects in Arthritic Joints with Dynamic Optical Tomography

机译：动态光学断层扫描成像关节炎关节中的血流动力学效应。

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摘要

Optical probing of hemodynamics is often employed in areas such as brain, muscular, and breast-cancer imaging. In these studies an external stimulus is applied and changes in relevant physiological parameters, e.g. oxy or deoxy-hemoglobin concentrations, are determined. In this work we present the first application of this method for characterizing joint diseases, especially effects of rheumatoid arthritis (RA) in the proximal-interphalangeal (PIP) finger joints. Using a dual-wavelength tomographic imaging system together with previously implemented model-based iterative image reconstruction schemes, we have performed dynamic imaging case studies on a limited number of healthy volunteers and patients diagnosed with RA. Inflating a sphygmomanometer cuff placed around the forearm we elicited a controlled vascular response. We observed pronounced differences between the hemodynamic effect occurring in healthy volunteers and patients affected by RA.
机译：血液动力学的光学探测通常用于大脑，肌肉和乳腺癌成像等领域。在这些研究中，施加了外部刺激并改变了相关的生理参数，例如确定氧或脱氧血红蛋白的浓度。在这项工作中，我们介绍了该方法在表征关节疾病，特别是类风湿关节炎（RA）在指间指间（PIP）手指关节中的作用方面的首次应用。使用双波长层析成像系统以及先前实施的基于模型的迭代图像重建方案，我们对有限数量的健康志愿者和诊断为RA的患者进行了动态成像案例研究。充气放置在前臂周围的血压计袖带，我们引起了受控的血管反应。我们观察到健康志愿者和RA患者的血液动力学效应之间存在明显差异。

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