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首页> 外文会议>Diffuse Optical Imaging of Tissue; Progress in Biomedical Optics and Imaging; vol.8 no.42; Proceedings of SPIE-The International Society for Optical Engineering; vol.6629 >Algorithms for Muscle Oxygenation Monitoring corrected for Adipose Tissue Thickness
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Algorithms for Muscle Oxygenation Monitoring corrected for Adipose Tissue Thickness

机译：校正脂肪组织厚度的肌肉氧合监测算法

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摘要

The measurement of skeletal muscle oxygenation by NIRS methods is obstructed by the subcutaneous adipose tissue which might vary between < 1 mm to more than 12 mm in thickness. A new algorithm is developed to minimize the large scattering effect of this lipid layer on the calculation of muscle haemoglobin / myoglobin concentrations. First, we demonstrate by comparison with ultrasound imaging that the optical lipid signal peaking at 930 nm is a good predictor of the adipose tissue thickness (ATT). Second, the algorithm is based on measurements of the wavelength dependence of the slope △A/△ρ of attenuation A with respect to source detector distance ρ and Monte Carlo simulations which estimate the muscle absorption coefficient based on this slope and the additional information of the ATT. Third, we illustrate the influence of the wavelength dependent transport scattering coefficient of the new algorithm by using the solution of the diffusion equation for a two-layered turbid medium. This method is tested on experimental data measured on the vastus lateralis muscle of volunteers during an incremental cycling exercise under normal and hypoxic conditions (corresponding to 0, 2000 and 4000 m altitude). The experimental setup uses broad band detection between 700 and 1000 nm at six source-detector distances. We demonstrate that the description of the experimental data as judged by the residual spectrum is significantly improved and the calculated changes in oxygen saturation are markedly different when the ATT correction is included.
机译：皮下脂肪组织阻碍了NIRS方法对骨骼肌氧合的测量，皮下脂肪组织的厚度可能在<1 mm至大于12 mm之间变化。开发了一种新算法，以最小化此脂质层在肌肉血红蛋白/肌红蛋白浓度计算中的大散射效应。首先，通过与超声成像的比较，我们证明在930 nm处达到峰值的光学脂质信号是脂肪组织厚度（ATT）的良好预测指标。其次，该算法基于衰减A的斜率△A /△ρ相对于源探测器距离ρ的波长相关性的测量以及蒙特卡洛模拟，后者基于该斜率和附加的信息估计肌肉吸收系数。 ATT。第三，我们利用两层浑浊介质的扩散方程解，说明了新算法的波长相关输运散射系数的影响。该方法在正常和低氧条件下（分别对应于0、2000和4000 m高度）的增量自行车运动过程中，在志愿者的股外侧肌上测得的实验数据上进行测试。实验装置在六个光源-探测器距离处使用700至1000 nm之间的宽带探测。我们证明通过残余光谱判断的实验数据描述得到了显着改善，并且当包括ATT校正时，氧饱和度的计算变化显着不同。

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