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Ideal Observer Comparison between Tomographic and Projection x-Ray Images of the Breast

机译：乳房X线断层摄影图像和投影X射线图像之间的理想观察者比较

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摘要

The image data from 348 breast CT studies performed on patient volunteers in a Phase II clinical trial were used in a pre-whitened matched filter (PWMF) model observer study. This computer-based investigation simulated the addition of spherical lesions of various diameters to the breast data sets, and a series of images with different slice thicknesses ranging from 0.3 mm to 44 mm were created by voxel averaging. The PWMF was tailored to each slice thickness, and signal known exactly receiver operating characteristic analysis was performed. A total of 1000 lesions and "non-lesions" were simulated for each diameter on each breast data set. Receiver operating characteristic (ROC) curve analysis was performed, and sensitivity at 95% specificity was computed. Thin slice imaging as with breast CT demonstrated significantly better sensitivity than thick slice images as with mammography, with improvements in sensitivity ranging from 5% to 50%.
机译：在一项II期临床试验中，对患者志愿者进行的348例乳腺CT研究的图像数据已用于预先变白的匹配过滤器（PWMF）模型观察者研究中。这项基于计算机的调查模拟了向乳房数据集添加各种直径的球形损伤的情况，并通过体素平均创建了一系列切片厚度从0.3毫米到44毫米不等的图像。针对每个切片厚度定制PWMF，并执行准确已知的接收器工作特性分析的信号。在每个乳房数据集上，每个直径总共模拟了1000个病变和“非病变”。进行受试者工作特征（ROC）曲线分析，并计算95％特异性下的灵敏度。乳腺CT的薄片成像显示出比乳腺X线摄影的厚层成像显着更好的敏感性，敏感性提高了5％至50％。

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