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首页> 外文会议>International symposium on halogenated persistent organic pollutants >COMPARATIVE PHARMACOKINETICS OF PERFLUOROHEXANESULFONATE (PFHxS) IN RATS AND MONKEYS
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COMPARATIVE PHARMACOKINETICS OF PERFLUOROHEXANESULFONATE (PFHxS) IN RATS AND MONKEYS

机译：大鼠和猴子中全氟辛基磺酸盐（PFHxS）的比较药代动力学

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Perfluorohexanesulfonate (PFHxS) has been found in biological samples from wildlife and humans. The geometric mean half-life of serum elimination of PFHxS in humans has been estimated to be 7.3 years (95% CI 5.8-9.2 years). We undertook a series of studies to establish pharmacokinetic parameters in non-human species. Male (M) and female (F) monkeys were given a single intravenous (IV) dose of K+PFHxS and serum and urine PFHxS concentrations were followed for 171 d. M and F rats were given single oral doses of 1, 10, or 100 mg/kg K+PFHxS and urine and feces were collected over 96 h and serum and liver collected at 96 h. Jugularcannulated M and F rats were given either IV or oral single 10 mg/kg doses of K+PFHxS and serum concentrations of PFHxS were followed for 24 h. M and F rats were given a single IV dose of 10 mg/kg, and serum, feces, and urine were collected weekly for 10 weeks. All PFHxS analyses utilized LC-MSMS methods. Pharmacokinetic parameters were determined by WinNonlin?software. Volumes of distribution indicated predominant extracellular distribution. Mean serum elimination half-lives were 141 and 87 d for M and F monkeys and ca. 30 and 1.5 d for M and F rats.
机译：在野生动植物和人类的生物样品中发现了全氟己烷磺酸盐（PFHxS）。血清消除人体内PFHxS的几何平均半衰期估计为7.3年（95％CI 5.8-9.2年）。我们进行了一系列研究，以建立非人类物种的药代动力学参数。给雄性（M）和雌性（F）猴子单次静脉内（IV）剂量的K + PFHxS，并跟踪血清和尿液PFHxS的浓度171 d。对M和F大鼠分别给予1、10或100 mg / kg K + PFHxS的口服剂量，并在96小时内收集尿液和粪便，并在96小时内收集血清和肝脏。对颈静脉插管的M和F大鼠进行静脉或口服单次10 mg / kg剂量的K + PFHxS，并跟踪PFHxS的血清浓度24小时。对M和F大鼠给予10 mg / kg的单次IV剂量，并在10周内每周收集一次血清，粪便和尿液。所有PFHxS分析均使用LC-MSMS方法。药代动力学参数由WinNonlin？软件确定。分布的体积表明主要的细胞外分布。 M和F猴的平均血清消除半衰期为141和87 d，大约为8d。 M和F大鼠30和1.5 d。

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