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首页> 外文会议>International symposium on halogenated persistent organic pollutants >EXPOSURE TO PCBS AND HYPERTENSION IN THE ANNISTON COMMUNITY HEALTH SURVEY
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EXPOSURE TO PCBS AND HYPERTENSION IN THE ANNISTON COMMUNITY HEALTH SURVEY

机译：安尼斯顿社区健康调查中的PCBs暴露和高血压

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摘要

Environmental exposures that may contribute to the development of essential hypertension are not clearly understood. We have studied factors associated with the risk of hypertension in residents of Anniston, Alabama who live near a plant that manufactured polychlorinated biphenyls (PCBs) between 1929 and 1971. A total of 759 Anniston residents had multiple measurements of blood pressure and information on demographic factors, medications, smoking, and exercise collected in 2005-2007. They also provided blood samples for the analysis of 35 PCBs and total serum lipids. Rates of hypertension increased significantly (p<0.05) with age, concentrations of serum PCBs and body mass index (BMI) and were higher in African-Americans than in Caucasians. Hypertension was not associated with total serum lipid levels, gender, smoking or frequency of exercise. Odds ratios (ORs) for elevated diastolic blood pressure in relation to total serum PCBs were above four in those not on anti-hypertensive medication (OR=4.49, 95% CI 1.34-14.99) after adjustment for established risk factors for hypertension and were elevated, but to a lesser degree for systolic hypertension (OR=3.87, 95% CI 1.13-13.17).
机译：可能导致原发性高血压发展的环境暴露尚不清楚。我们研究了阿拉巴马州安尼斯顿居民的高血压风险相关因素，这些居民住在1929年至1971年之间​​生产多氯联苯（PCB）的工厂附近。总共759名安尼斯顿居民进行了多次血压测量和人口统计学信息，药物，吸烟和运动收集于2005-2007年。他们还提供了血液样本，用于分析35种多氯联苯和总血脂。高血压的发生率随着年龄，血清多氯联苯的浓度和体重指数（BMI）的增加而显着增加（p <0.05），并且非洲裔美国人的高血压率高于白种人。高血压与总血脂水平，性别，吸烟或运动频率无关。调整了既定的高血压危险因素后，未接受抗高血压药物治疗的舒张压相对于总血清PCBs的几率（OR）高于4（OR = 4.49，95％CI 1.34-14.99），且升高，但对于收缩期高血压程度较小（OR = 3.87，95％CI 1.13-13.17）。

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  • 会议地点 Beijing(CN)
  • 作者

    Goncharov A; Bloom MS; Pavuk M; Carpenter DO;

  • 作者单位

    Anniston Environmental Health Research Consortium Department of Environmental Health Sciences,School of Public Health,University at Albany,Rensselaer,NY 12144;

    Anniston Environmental Health Research Consortium Department of Environmental Health Sciences,School of Public Health,University at Albany,Rensselaer,NY 12144 Institute for Health and the Environment,University at Albany,Rensselaer,NY 12144;

    Anniston Environmental Health Research Consortium Agency for Toxic Substances and Disease Registry,Centers for Disease Control and Prevention,Atlanta,GA 30341;

    Anniston Environmental Health Research Consortium Department of Environmental Health Sciences,School of Public Health,University at Albany,Rensselaer,NY 12144 Institute for Health and the Environment,University at Albany,Rensselaer,NY 12144;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 环境分析化学;
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